李毅,中国科学院脑科学与智能技术卓越创新中心(神经科学研究所)研究员。以第一或通讯作者(含并列)在Nature、Cell、Developmental Cell等国际知名学术期刊上发表了多篇与神经轴突再生、脊髓损伤后修复及功能重建相关的研究工作。2021年加入中国科学院担任中枢神经损伤与功能重建研究组组长。获得国家海外高层次人才引进计划,国家自然科学基金重大研究计划培育项目、国际(地区)合作项目,上海市领军人才(海外)项目资助。 近年发表文章 1.Chengyue Ji#, Yunfan Zhang#, Zeyu Lin#, Yi Li*. (2024) Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice. BioRxiv https://doi.org/10.1101/2024.11.16.621796 ( *通讯作者) 2.Xiaorong Pan#, Yiqing Hu#, Gaowei Lei, Yaxuan, Wei, Jie Li, Tongshu Luan, Yunfan Zhang, Yuanyuan Chu, Yu Feng, Wenrong Zhan, Chunxia Zhao, Frédéric A. Meunier, Yifan Liu, Yi Li*, and Tong Wang*. (2024) Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical Stress. JournalofCellBiology 223(8):e202206046 ( *共同通讯作者) 3.Fei Wang#, Kendra Ruppell#, Songlin Zhou#, Yun Qu , Jiaxin Gong, Ye Shang, Jinglin Wu,Xin Liu,Wenlin Diao,Yi Li*, Yang Xiang*. (2023) Gliotransmission and adenosine signaling promote axon regeneration. Developmental Cell 58(8):660-676.e7.(*共同通讯作者) 4.Faith H. Brennan, Yang Li, Cankun Wang, Anjun Ma, Yi Li, Nicole Pukos, Warren A. Campbell, Kristina G. Witcher, Zhen Guan, Kristina A. Kigerl, Jodie C.E. Hall Jonathan P. Godbout, Andy J. Fischer, Dana M. McTigue, Zhigang He, Qin Ma, and Phillip G. Popovich. (2022) Microglia coordinate cellular interactions during spinal cord repair in mice. Nature Communication 13:4096 5.Li Y#, He X#, Kawaguchi R#, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich P, Geschwind D, He Z*. (2020)Microglia-organized Scar-free spinal cord repair in neonatal mice.Nature587: 613-618 6.Wang J#, He X#, Meng H,Li Y, Dmitriev P, Tian F, Page J, Lu Q, He Z* (2020)Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and MicrogliaNeuron108: 43841 7.Boaz Barak#, Zicong Zhang, Yuanyuan Liu, Ariel Nir, Sari S Trangle, Michaela Ennis, Kirsten M Levandowski, Dongqing Wang, Kathleen Quast, Gabriella L Boulting,Li Y,Dashzeveg Bayarsaihan, Zhigang He*, Guoping Feng* (2019)Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug;Nature neuroscience22(5): 700 8.Chen B#,Li Y#, Yu B#, Zhang Z, Brommer B, Williams, P.R, Liu Y, Hegarty, S. V, Zhu, S, Zhu, J, Guo, H, Lu, Y, Gu, X*, and He, Z*. (2018)Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations.Cell174(3): 521-535 (#共同第一作者) 9.Liu Y#, Wang X#, Li W#, Zhang Q,Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z*. (2017)A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.Neuron95(4): 817-833 10.Norsworthy MW#, Bei F, Kawaguchi R, Wang Q, Tran NM,Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z*. (2017)Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.Neuron94(6): 1112-1120