目前，已经取得了一系列原创性成果包括：1)开发了人星形胶质细胞直接重编程为神经类器官方法以及脊髓类器官制备新方法，开拓了脊髓类器官移植治疗脊髓损伤的新策略；2）开发了神经类器官冻存以及在脑疾病应用的新技术；3）揭示Protocadherin在精神分裂症发病机制中的关键作用；4）发现新的细胞重编程因子BRD3R以及揭示BET家族蛋白的小分子抑制剂促进体细胞重编程新功能。相关成果以通讯作者和第一作者（含共同）发表在Nature Biomedical Engineering, Nature Neuroscience, Biomaterials, Nature Communications, Cell Reports, iScience, Cell Reports Methods等国际学术刊物上。申请与获批7项国家专利。获得科技部2030“脑科学与类脑研究”重大项目(骨干)，国家自然科学基金，上海市自然科学基金和企业横向课题等多个项目支持。 1. Weiwei Xue*, Huijuan Li, Jinhong Xu, Xiao Yu, Linlin Liu, Huihui Liu, Rui Zhao and Zhicheng Shao*. Effective cryopreservation of human brain tissue and neural organoids, Cell Reports Methods, 2024, 4, 100777. 2. Peng Deng#, Shoupei Liu# , Yaoguang Zhao#, Xinxin Zhang , Yufei Kong, Linlin Liu, Yujie Xiao, Shasha Yang, Jiahao Hu, Jixiong Su, Ang Xuan, Jinhong Xu, Huijuan Li, Xiaoman Su, Jingchuan Wu, Yuli Jiang, Yu Mu, Zhicheng Shao*, Cihang Kong*, Bo Li*. Long-working-distance high-collection-efficiency three-photon microscopy for in vivo long-term imaging of zebrafish and organoids. iScience, 2024, 27, 110554 3. Qi Fan #, Hanze Wang #, Tianyi Gu, Huihui Liu, Peng Deng, Bo Li，Hui Yang*，Ying Mao*，Zhicheng Shao*. Modeling the precise interaction of glioblastoma with human brain region-specific organoids. iScience, 2024, 27, 109111. 4. Weiwei Xue#*, Bo Li#, Huihui Liu#, Yujie Xiao, Bo Li, Lei Ren, Huijuan Li, Zhicheng Shao*. Generation of Dorsoventral Human Spinal Cord Organoids via Functionalizing Composite Scaffold for Drug Testing. iScience, 2023, 26, 105898. 5. Jinhong Xu#, Shi Fang#, Suixin Deng, Huijuan Li, Xiaoning Lin, Yongheng Huang, Sangmi Chung, Yousheng Shu and Zhicheng Shao*. Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nature biomedical engineering, 2023,7, 253–269 6. Jinhong Xu, Shi Fang, Naweng Wang, Bo Li, Yongheng Huang, Qi Fan, Jingyi Shi, Huihui Liu, Zhicheng Shao*. Dual‑specificity Tyrosine Phosphorylation‑regulated Kinase Inhibitor ID‑8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression. Stem Cell Rev Rep. 2022 ;18(6):2074-2087 7. Zhicheng Shao, Ricardo Raúl Cevallos and Kejin Hu，Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium., Nuclear Reprogramming: Methods and Protocols, Methods in Molecular Biology, 2021, vol. 2239, Chapter 7 8. Gun-Hoo Park #, Haneul Noh #, Zhicheng Shao, Peiyan Ni, Yiren Qin, Dongxin Liu, Cameron P Beaudreault, Joy S Park, Chiderah P Abani, James M Park, Derek T Le, Sasha Z Gonzalez, Youxin Guan, Bruce M Cohen, Donna L McPhie, Joseph T Coyle, Thomas A Lanz, Hualin S Xi, Changhong Yin, Weihua Huang, Hae-Young Kim, Sangmi Chung. Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nature neuroscience 2020, 23, 1352-1364. 9. Jie Zhao#, Zesen Ye#, Jun Yang#, Qiang Zhang, Wenjun Shan, Xiumin Wang, Zhanxiang Wang, Shefang Ye, Xi Zhou, Zhicheng Shao*, Lei Ren*. Nanocage encapsulation improves antiepileptic efficiency of phenytoin. Biomaterials 2020, 240, 119849. 10. Shao Z#, Noh H#, Bin Kim W, Ni P, Nguyen C, Cote S E, Noyes E, Zhao J, Parsons T, Park J M, Zheng K, Park J J, Coyle J T, Weinberger D R, Straub R E, Berman K F, Apud J, Ongur D, Cohen B M, McPhie D L, Rapoport J L, Perlis R H, Lanz T A, Xi H S, Yin C, Huang W, Hirayama T, Fukuda E, Yagi T, Ghosh S, Eggan K C, Kim H Y, Eisenberg L M, Moghadam A A, Stanton P K, Cho J H*, Chung S*. Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nature Neuroscience 2019, 22 (2), 229-242.