近五年国家级课题 1. SPHK1/S1P/S1PR1信号轴介导NLRP3炎症小体在肿瘤癌前病变致病机理研究，国家自然科学基金委员会，57万元； 2. 口腔癌分子分型和精准预防诊治标志物的研究，科技部，320万元。 近五年代表性论文 1. Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans，通讯作者，Science Advances，2022 8(21):9120-9134 (SCI，13.6) 2. Improving the diagnostic efficacy of squamous cell carcinoma antigen for oral squamous cell carcinoma via saponin disruption of serum extracellular vesicles，通讯作者，Clin Chim Acta， 2022 525:40-45（SCI，5.0） 3. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells ，通讯作者，Mol Oncol，2023 17(8):1678-1691（SCI，6.6） 4. Bitter melon derived extracellular vesicles enhance the therapeutic effects and reduce the drug resistance of 5-fluorouracil on oral squamous cell carcinoma，通讯作者，J Nanobiotechnology，2021 19(1):259-262（SCI，9.429） 5. An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy，通讯作者，J Nanobiotechnology，2020 18(1):100（SCI，10.435）