学术成就   长期从事风湿免疫疾病临床和基础研究，在类风湿关节炎领域取得多项创新和突破，探索发现了类风湿关节炎存在6个高风险基因分型；主持研究雷公藤内酯醇新型衍生物LLDT-8治疗类风湿关节炎的分子机制，发现了其抑制类风湿关节炎滑膜成纤维细胞的炎症反应、促进细胞凋亡的信号通路和作用靶点，为LLDT-8的临床应用提供了充分的药理学依据；基于多组学分析技术揭示了部分类风湿关节炎病人对肿瘤坏死因子α抑制剂疗效不佳的新机制,对类风湿关节炎的发病机制和临床药物治疗方案选择具有重大指导意义。在他带领下医院风湿免疫科经过50年建设和发展成为了国家中医药管理局区域诊疗中心、国家中医药管理局风湿病重点学科、上海市中西医结合关节病临床诊疗基地等重点学科。专科现有床位153张，年就诊28万余人次，年住院1万余人次，45%患者来自上海市外。在复旦大学发布的《2013年度中国医院最佳专科声誉排行榜》和《2015年度全国医院科室排行榜》中科室分别获提名，在2019年度上海市三甲医院科研竞争力排名中位列第三。2014年起先后主持“上海市中医药三年行动计划—中西医结合关节病临床诊疗基地”、“国家中医院管理局“十三五”国家区域诊疗中心”和“上海市中西医结合关节病专科联盟”项目，与上海市内、华东地区近80家二、三级医院和社区卫生服务中心建立三级专病诊疗网络，完善、推广中西医结合关节病诊疗方案，构建中西医临床协作平台和多学科一体化诊疗平台，提高周边区域关节病诊疗水平。 科研获奖情况 2020年《强直性脊柱炎和类风湿关节炎致病机理及诊疗策略的关键技术研究》获上海市科技进步一等奖 排名4 2020年《消痹膏治疗膝骨关节炎的临床和实验研究》获中国中西医结合学会科学技术三等奖 排名1 2020年《秦氏消痹膏治疗膝骨关节炎的临床和实验研究》获上海中西医结合科学技术三等奖 排名1 2020年《秦氏消痹膏治疗膝骨关节炎的临床和实验研究》获上海中医药科技三等奖 排名1 2017年《陈氏清肺方治疗类风湿关节炎并发间质性肺炎（RA-ILD）的临床和实验研究》获上海市中西医结合科学技术三等奖  排名2 2016年《尪痹片等痹症系列药治疗类风湿性关节炎的基础与临床辩证应用研究》获中国中西医结合学会科学技术奖二等奖  排名9 2016年《“从肾论治”在针药结合治疗类风湿关节炎的临床应用及相关机制》获上海市科技进步奖三等奖  排名2 2016年《“从肾论治”在针药结合治疗类风湿关节炎的临床应用及相关机制》获第六届上海中医药科技奖二等奖  排名3 2015年《消痹膏治疗类风湿关节炎的临床和实验研究》获上海市中西医结合科学技术奖三等奖 排名1 2012年《（-）-表没食子儿茶素没食子酸酯对类风湿关节炎的免疫调节机理研究》或上海市中西医结合科学技术奖三等奖 排名1 2012年《（-）-表没食子儿茶素没食子酸酯对类风湿关节炎的免疫调节机理研究》获上海市科学技术成果 排名1 2011年《Ergotope肽段免疫干预类风湿关节炎的研究》获上海医学科技奖三等奖 排名1 2010年《问荆合剂治疗类风湿关节炎的临床和实验研究》获上海市中西医结合科学技术奖三等奖 排名1 2013年《中药有效成分配伍治疗类风湿关节炎的研究》获河北省中医药学会科学技术奖一等奖  排名8 2009年《基于内毒素肠渗漏机制的健脾活血方抗酒精肝损伤机理研究》获中国中西医结合学会科学技术奖二等奖  排名10 发明专利 1.一种清热消肿止痛的中药制剂及其制备方法（ZL 201310360885.1） 2.一种类风湿关节炎手部矫正器（ZL201821978707.X）（实用新型 排名2） 著作 1.《风湿免疫性疾病诊疗标准》，副主编，上海科学普及出版社，中国上海，2015年 2.《秦亮甫临床治病录》，主编，科学出版社，中国上海，2017年 3.《秦亮甫临证思辨与医案集萃》，主编，上海科学技术出版社，中国上海，2018年 4.《风湿病中医临床诊疗丛书.炎性肌病分册》，主编，中国中医药出版社，中国上海，2020年 5.《中西医结合临床风湿病学》，副主编，中国中医药出版社，中国上海，2021年 重要论文 英文论文 1. Yuning Ma, Mengyan Wang, Jinchao Jia, Jianfen Men, Jialin Teng, Dehao Zhu, Hui Shi, Yue Sun, Yutong Su, Honglei Liu, Xiaobing Cheng, Junna Ye, Huihui Chi, Tingting Liu, Xia Chen, Liyan Wan, Zhuochao Zhou, Fan Wang, Dongyi He*, Chengde Yang*, Qiongyi Hu*. Enhanced type I interferon signature induces neutrophil extracellular traps enriched in mitochondrial DNA in adult-onset Still's disease. J Autoimmun. 2022 Feb;127:102793. IF: 7.094 2. Huijuan Wang†, Runrun Zhang†, Jie Shen, Yehua Jin, Cen Chang, Mengjie Hong, Shicheng Guo*,·Dongyi He*.Circulating Level of Blood Iron and Copper Associated with Inflammation and Disease Activity of Rheumatoid Arthritis. Biol Trace Elem Res. 2022 Mar 28. IF:3.738 3. Guo S†, Jin Y†, Zhou J†, Zhu Q, Jiang T, Bian Y, Zhang R, Chang C, Xu L, Shen J, Zheng X, Shen Y, Qin Y, Chen J, Tang X, Cheng P, Ding Q, Zhang Y, Liu J, Cheng Q, Guo M, Liu Z, Qiu W, Qian Y, Sun Y, Shen Y, Nie H, Schrodi SJ*, He D*.MicroRNA Variants and HLA-miRNA Interactions are Novel Rheumatoid Arthritis Susceptibility Factors. Front Genet. 2021 Oct 29;12:747274. doi: 10.3389/fgene.2021.747274. IF:4.559 4. Zhang R†, Zhou X†, Jin Y, Chang C, Wang R, Liu J, Fan J, He D*.Identification of differential key biomarkers in the synovial tissue between rheumatoid arthritis and osteoarthritis using bioinformatics analysis. Clin Rheumatol. 2021 Dec;40(12):5103-5110. 1.IF:2.982 5. Xinpeng Zhou#, Duoli Xie#, Jie Huang, Aiping Lu, Rongsheng Wang, Yehua Jin, Runrun Zhang, Cen Chang, Lingxia Xu, Linshuai Xu, Junyu Fan, Chao Liang*, Dongyi He*.Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis[J]. Front Immunol,2021, 605616.IF:7.564. 6. Guo S†, Xu L†, Chang C†, Zhang R, Jin Y, He D*. Epigenetic regulation mediated by methylation in the pathogenesis and precision medicine of rheumatoid arthritis. Front Genet.2020 Aug 4;11:811. doi: 10.3389/fgene.2020.00811. IF:3.258 7. Liu Z; Shen J; Shen Z; He D*. The clinical efficacy of traditional Chinese medicine in the treatment of rheumatoid arthritis with interstitial lung disease, Medicine (Baltimore). 2020 Oct 9;99(41):e22453.  IF:1.552 8. Song J, Liu H, Zhu Q, Miao Y, Wang F, Yang F, Cheng W, Xi Y, Niu X, He D*, Chen G*. T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB. BioMed Research International. Volume 2018, Article ID 4901591, 8 pages.https://doi.org/10.1155/2018/4901591. IF : 2.476 9. Guo S†, Liu J†, Jiang T, Lee D, Wang R, Zhou X, Jin Y, Shen Y, Wang Y, Bai F, Ding Q, Wang G, Zhang J, Zhou X*, Schrodi SJ*, He D*.(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.Sci Rep. 2019 Aug 1;9(1):11155. doi: 10.1038/s41598-019-47411-1. IF:4.011 10. Guo S, Wang R, Jiang T, Bai F, Ding Q, Ma Y, Wang Y, Yang Y, Wang X, Tang L, Nie H, Wang J, He D*. Alterations and diagnosis potential of serum lipid profiles in rheumatoid arthritis patints. Int J Clin Exp Pathol, 2017,10(3):3503-3509. IF:1.581 11. He D†, Zhu Q†, Zhou Q, Qi Q, Sun H, Zachariah LM, Wang G, Reveille JD, Guan Y, Zhou X. Clin Rheumatol. Correlation of serum MMP3 and other biomarkers with clinical outcomes in patients with ankylosing spondylitis: a pilot study. Clin Rheumatol.2017 Apr 22.IF: 2.042 12. He D, Liu J, Hai Y, Zhu Q, Shen Y,Guo S, Zhang W, Zhou X. Increased DOT1L in synovial biopsies of patients with OA and RA. Clin Rheumatol. Published online:13 Dec 2017https://doi.org/10.1007/s10067-017-3941-x. IF:2.365 13. Yin J †, He D †, Jiang L, Cheng F, Guo Q, Huang S, Zeng X, Liu Y, Brown MA, Xu H. Influence of Cigarette Smoking on Rheumatoid Arthritis Risk in the Han Chinese Population. Front Med (Lausanne). 2017 Jun 15;4:76. doi: 10.3389/fmed.2017.00076. PMID: 28674691; PMCID: PMC5475383. IF:2.365 14. Guo S, Jiang T, Wang R, Shen Y , Zhu X, B F, Ding Q, Chen G*, He D*. Genome-wide  DNA methylation patterns in CD4+ T reveal significant contribution of DNA methylation to rheumatoid arthritis. Mod Rheumatol, 2016; Early Online: 1–7. IF:1.843; 15. Shen Y†, Jiang T †, Wang R, He S, Guo M, Zuo J*, He D*. (5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway. BMC Complement Altern Med. 2015 Mar 24;15:77. IF: 2.02; Times Cited: 1 16. Xu Y †, Zhu Q †, Song J, Liu H, Miao Y, Yang F, Wang F, Cheng W, Xi Y, Niu X, He D*, Chen G*. Regulatory effect of iguratimod on the balance of th subsets and inhibition of inflammatory cytokines in patients with rheumatoid arthritis. Mediators Inflamm. 2015;2015:356040. IF: 3.236; 17. He D†, Wang J† Yi L, Guo X, Guo S,  Guo G, Tu W, Wu W, Yang L, Xiao R, Li Y, Chu H, Jin L, Zou H, Reveille JD, Assassi S, Mayes MD,  Zhou X*. Association of the HLA-DRB1 with scleroderma in Chinese population. PLoS One. 2014; 9(1):e87363. IF: 3.234; Times Cited: 4 18. Zhang W †, Cong XL †, Qin YH, He ZW, He DY*, Dai SM*. IL-18 upregulates the production of key regulators of osteoclastogenesis from fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2013; 36(1):103-9. IF:2.208 19. He D*, Bai F, Zhang S, Jiang T, Shen J, Zhu Q, Yue T, Shao L, Gao Y, Feng Y, Weng X, Zou H, Zhang Y, Zhang W*. High incidence of tuberculosis infection in rheumatic diseases and impact for chemoprophylactic prevention of tuberculosis activation during biologics therapy. Clin Vaccine Immunol. 2013; 20(6):842-7. IF:2.47 20. Xie WL, Li ZL, Xu Z, Qu HR, Xue L, Su X, Wei QH, Wang H, Li MY, Zhao FT, Jiang LD, Zhang J, Wan WG, Dai M, Yang CD, Guan JL*, Su L, Zhao DB, He DY*, Xu HJ, Zou HJ, Bao CD. The risk factors for nosocomial infection in chinese patients with active rheumatoid arthritis in shanghai. ISRN Rheumatol. 2012; 2012:215692. IF:4.475 21. Fan LY†*, He DY†, Wang Q†, Zong M, Zhang H, Yang L, Sun LS. Citrullinated vimentin stimulates proliferation, pro-inflammatory cytokine secretion, and PADI4 and RANKL expression of fibroblast-like synoviocytes in rheumatoid arthritis. Scand J Rheumatol. 2012; 41(5):354-8. IF:2.527 22. He DY, Dai SM*. Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine. Front Pharmacol. 2011; 2:10. IF:3.802 23. Niu X †*, He D†*, Deng S, Li W, Xi Y, Xie C, Jiang T, Zhang JZ, Dong C, Chen G*. Regulatory immune responses induced by IL-1 receptor antagonist in rheumatoid arthritis. Mol Immunol. 2011; 49(1-2):290-6. IF:2.973 24. Niu X, He D, Zhang X, Yue T, Li N, Zhang JZ, Dong C, Chen G. IL-21 regulates Th17 cells in rheumatoid arthritis. Hum Immunol. 2010; 71(4):334-41. IF: 2.872; Times Cited: 86 25. Nie H†, Zheng Y †, Li R †, Guo TB, He D, Fang L, Liu X, Xiao L, Chen X, Wan B, Chin YE, Zhang JZ*. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med. 2013; 9(3):322-8. IF: 28.054; Times Cited: 158 26. Zhu S†, Pan W†, Song X, Liu Y, Shao X, Tang Y, Liang D, He D, Wang H, Liu W, Shi Y, Harley JB, Shen N*, Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med. 2012; 18(7):1077-86. IF: 22.864; Times Cited: 169 27. Fan L†*, Zong M†, Gong R, He D, Li N, Sun LS, Ye Q, Yu S. PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients. Int. J. Biol. Sci. 2017, 13(3): 358-366. IF: 3.982 28. Wang G, Bi ZL, Li x, Z, Zhao D, Chen J, He D, Wang CN, Duenas H, Skljarevski V, Yue L*. Efficacy and safety of duloxetine in Chinese patients with chronic pain due to osteoarthritis: a randomized, double-blind, placebo-controlled study. Osteoarthritis and Cartilage. (2017) 1-7. IF:4.472 29. Shi C†, Li H†, Couturier JP, Yang K, Guo X, He D, Lewis DE, Zhou X*. Allele specific expression of MICA variants in human fibroblasts suggests a pathogenic mechanism. Open Rheumatol J. 2015 Aug 26;9:60-4. Times Cited: 1 30. Wei L, Zhang C, Chen HY, Zhang ZJ, Ji ZF, Yue T, Dai XM, Zhu Q, Ma LL, He DY, Jiang LD*. Dopamine receptor DR2 expression in B cells is negatively correlated with disease activity in rheumatoid arthritis patients.Immunobiology. 2015 Mar;220(3):323-30. IF: 3.044 31. Jiang L†, Yin J †, Ye L †, Yang J †, Hemani G, Liu AJ, Zou H, He D, Sun L, Zeng X, Li Z, Zheng Y,et al. Novel risk loci for rheumatoid arthritis in han chinese and congruence with risk variants in europeans. Arthritis Rheum. 2014. IF: 7.871; Times Cited: 21 32. Zheng Y, Sun L, Jiang T, Zhang D, He D, Nie H. TNFα promotes Th17 cell differentiation through IL-6 andIL-1β produced by monocytes in rheumatoid arthritis. Journal of Immunology Research, Volume 2014, Article ID 385352, 12 pages. IF: 3.064; Times Cited: 5 33. Gui H†, Liu X †, Wang ZW, He DY, Su DF, Dai SM*. Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis. Rheumatology (Oxford). 2014; 53(5):802-9. IF:4.475 34. Wang J, Yi L, Guo X, He D, Li H, Guo G, Wang Y, Zou H, Gu Y, Tu W, Wu W, Yang L, Xiao R, Lai S, Assassi S, Mayes MD, Zhou X. Lack of association of the CD247 SNP rs2056626 with systemic sclerosis in Han Chinese. Open Rheumatol J. 2014 Oct 2;8:43-5. Times Cited: 5 35. Zhang X, Zhang F, Wu D, Bao C, Zhu P, Zhang X, Huang C, He D, Tao Y, Fang Y, Gu J, Wu H, Sun L, Yang X, Huang F, Xu H, Zhao D, Zhang M, Zheng Y, Li Z*. Safety of infliximab therapy in rheumatoid arthritis patients with previous exposure to hepatitis B virus. Int J Rheum Dis. 2013; 16(4):408-12. IF: 1.771; Times Cited: 4 36. Fan L*†, Wang Q†, Liu R†, Zong M, He D, Zhang H, Ding Y, Ma J. Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2012; 14(6):R266. IF: 4.302; Times Cited: 17 37. Li Y, Jiang L, Zhang S, Yin L, Ma L, He D, Shen J. Methotrexate attenuates the Th17/IL-17 levels in peripheral blood mononuclear cells from healthy individuals and RA patients. Rheumatol Int. 2012 Aug;32(8):2415-22. IF: 2.214; Times Cited: 26 38. Hu C, Qian L, Miao Y, Huang Q, Miao P, Wang P, Yu Q, Nie H, Zhang J, He D, Xu R, Chen X, Liu B, Zhang D. Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis. Cell Mol Immunol. 2012 May;9(3):245-54. IF: 3.419; Times Cited: 28 39. Ma X, He L, He D, Xu J*. Chloroquine keratopathy of rheumatoid arthritis patients detected by in vivo confocal microscopy. Curr Eye Res. 2012; 37(4):293-9. IF: 1.71; Times Cited: 6 主要中文论文： 1.雷公藤—抗风湿新策略.中华风湿病学杂志.2018,22(3):1-3. 2.秦亮甫教授辨治痛风经验撷英.上海中医药大学学报,2011,25(6):1-2. 3.突变型瓜氨酸波形蛋白抗体在类风湿关节炎诊断中的意义. 现代免疫学,2010,30(4):318-313. 4.（-）-表没食子儿茶素没食子酸酯对胶原诱导性关节炎小鼠免疫调节机制研究. 中华风湿病学杂志. 2009,13( 8):538-541. 5.葡萄糖6-磷酸异构酶检测在类风湿关节炎中的意义.现代免疫学.2008,28(4):326-330. 6. 问荆合剂对胶原诱导关节炎大鼠滑膜细胞分泌TNF-α、IL-β水平的影响. 现代免疫学. 2006,26(1):69-71. 7.基于真实世界研究的类风湿关节炎血清阴性和血清阳性患者的临床特点及预后研究. 中华风湿病学杂志. 2021,25(05）：307-315. 8.类风湿关节炎成纤维样滑膜细胞lncRNA-miRNA-mRNA网络构建及关键基因预测. 中国医药导报. 2021,18(09):12-16+197. 9.基于数据挖掘及网络药理研究古方治疗强直性脊柱炎的用药规律及相关药理分析. 天然产物研究与开发. 2021,33(10):1769-1782. 10.甲氨蝶呤 来氟米特药物相关基因多态性在类风湿关节炎患者中的基因型分布.中华风湿病学杂志. 2020,24(04):226-233,C1+226-233,C1. 11. 老年发病的类风湿关节炎诊治进展.老年医学与保健.2019 ,25 (1 ):3-7. 12.近十年中医外治法治疗类风湿性关节炎的研究概况.时珍国医国药.2019 ,30 (7):1703-1705. 13.雷藤舒(LLDT-8)通过提高MEKK2蛋白表达调控胶原诱导性关节炎小鼠Treg／Th17平衡.现代免疫学.2018,38(3):210-216. 14..LDDT-8对类风湿关节炎滑膜细胞NF-κB信号通路的影响.现代免疫学.2018,38(4):265-270. 15.何东仪治疗类风湿关节炎五法.上海中医药杂志,2018,52(5):20-23. 16. Dot1及其同源物的研究进展.复旦学报（医学版）,2018,45(4):555-560,577. 17. 新雷公藤衍生物雷藤舒对类风湿关节炎滑膜细胞基因表达的影响.上海中医药大学学报.2017,31(6):70-75. 18. 雷藤舒对TNF-α诱导的人类风湿关节炎滑膜成纤维细胞促凋亡、抗炎及对Ras-MAPKs信号通路的调节作用. 上海中医药大学学报, 2016, 30(3):82-87. 19. 辨治类风湿关节炎继发骨质疏松症的经验. 中医文献杂志, 2016,3:47-50. 20. 雷藤舒（LLDT-8）对成纤维样滑膜细胞分泌趋化因子的影响.现代免疫学,2016,36(6):448-454. 21. 消痹膏镇痛抗炎作用的实验研究.上海中医药大学学报, 2014,28(2):56-59. 22. 秦氏消痹膏外敷结合西药治疗湿热痹阻型类风湿关节炎70 例.上海中医药杂志,2014,48(4):67-70. 23. 226例类风湿关节炎患者医院感染临床分析与预防对策. 中华医院感染学杂志. 2013,23(4):803-805. 24. 雷藤舒在类风湿关节炎中免疫调节机制的研究。现代免医学.2012.32(３):239-243. 25. 补肾化瘀法对早期类风湿关节炎患者骨代谢的影响. 中医杂志. 2012,53(3):215-218. 26. 不同治疗方案对类风湿关节炎患者关节放射学评分骨密度及血清骨代谢标志物影响的研究. 中国药物与临床. 2012,12(10):1264-1269. 27. 抗突变型瓜氨酸波形蛋白检测在类风湿关节炎中的意义. 中国免疫学杂志. 2008,24:1028-1032. 28. 艾拉莫德对类风湿关节炎临床疗效及T辅助细胞亚群调节作用的研究[J].中华风湿病学杂志,2016,(2):93-99. 29.雷公藤多苷对rmMIF 诱导大鼠成纤维样滑膜细胞增殖及RANKL /OPG 表达的影响. 解放军医药杂志. 2013,25(4 ):10-14.