主要学术成就 一、主持课题 1. CLMP介导Connexin45-β-catenin复合体对先天性短肠综合征的致病机制研究、国家自然科学基金面上项目（82370525）、项目负责人、49万、2024.1.1-2027.12.31 2.儿童慢性假性肠梗阻早期精准诊断及规范化治疗、卫健委卓越项目（20234Z0004）、项目负责人、30万、2023.1.1-2025.12.31 3.CLMP与FLNA互作调控细胞紧密连接对先天性短肠发病机制研究、上海市自然科学基金（22ZR1441100）、项目负责人、20万、2022.4.1-2025.3.31 4.ACTG2新突变位点对巨膀胱-小结肠-肠蠕动不良综合征致病分子机制研究、国家自然科学基金面上项目（81974066）、项目负责人、60万、2020.01-2023.12 5.上海卫生健康系统重要薄弱学科建设项目、上海市卫健委（2019ZB0101）、学科带头人、150万、2019.8.1-2022.7.31 6.肠外营养相关胆汁淤积通过胆汁酸受体对肠道功能影响机制研究、上海市浦江人才资助项目（17PJD026）、项目负责人、20万、2017.9.1-2019.8.31 二、科技奖项 1.第五届妇幼健康科学技术奖科技成果奖一等奖，2023，第1完成人 2.上海医学科技青年奖，2021，第1完成人 3.国家教育部科学技术进步奖（推广类）二等奖，2015，第3完成人 4.国家科技部国家科学技术进步奖二等奖，2010，第5完成人 5.宋庆龄儿科医学奖，2010，第5完成人 三、发明专利 1.六磷酸肌醇钠在小儿短肠综合征肠道康复治疗中的应用，CN202210081616.0，发明专利 四、论文 1.Yan J, Zhao Y, Jiang L, Wang Y, Cai W. Decreased Expression of KLF4 Leading to Functional Deficit in Pediatric Patients with Intestinal Failure and Potential Therapeutic Strategy Using Decanoic Acid. 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Fish oil-based lipid emulsion alleviates parenteral nutrition-associated liver diseases and intestinal injury in piglets. JPEN J Parenter Enteral Nutr. 2022 Mar;46(3):709-720. 19.Xiao Y, Sun Y, Lu Y, Du J, Tian X, Cai W, Wang Y. Loss function of Bcr mutation causes gastrointestinal dysmotility and brain developmental defects. Neurogastroenterol Motil. 2021 Dec;33(12):e14190 20.Yan W, Xiao Y, Zhang Y, Tao Y, Cao Y, Liu K, Cai W, Wang Y. Monogenic mutations in four cases of neonatal-onset watery diarrhea and a mutation review in East Asia. Orphanet J Rare Dis. 2021 Sep 9;16(1):383 21.Xiao Y, Wang Y, Liu Y, Wang W, Tian X, Chen S, Lu Y, Du J, Cai W. A nonbile acid farnesoid X receptor agonist tropifexor potently inhibits cholestatic liver injury and fibrosis by modulating the gut-liver axis. Liver Int. 2021 Sep;41(9):2117-2131 22.Wang Y, Li Z, Wu JL, Zhang L, Liu M, Tan M, Botma A, Liu M, Mulder KA, Abrahamse-Berkeveld M, Cai W. 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Variants in the Enteric Smooth Muscle Actin γ-2 Cause Pediatric Intestinal Pseudo-obstruction in Chinese Patients. J Pediatr Gastroenterol Nutr. 2021 Jan 1;72(1):36-42. 27.Feng H, Zhang T, Yan W, Lu L, Tao Y, Cai W, Wang Y. Micronutrient deficiencies in pediatric short bowel syndrome: a 10-year review from an intestinal rehabilitation center in China. Pediatr Surg Int. 2020 Dec;36(12):1481-1487 28.Wang N, Yan W, Hong L, Lu L, Feng Y, Wu J, Tao Y, Ruan H, Tang Q, Cai W, Wang Y. Risk factors of parenteral nutrition-associated cholestasis in very-low-birthweight infants. J Paediatr Child Health. 2020 Nov;56(11):1785-1790 29.Zhang T, Wang Y, Yan W, Lu L, Tao Y, Jia J, Cai W. Microbial alteration of small bowel stoma effluents and colonic feces in infants with short bowel syndrome. J Pediatr Surg. 2020 Jul;55(7):1366-1372. 30.Yan JK, Zhang T, Dai LN, Gu BL, Zhu J, Yan WH, Cai W, Wang Y. 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