1.主持课题 (1)上海市卫生健康委员会科研基金面上项目,201940395,超声引导神经调控对创伤后复杂性区域疼痛综合征CRPS(Ⅱ型)治疗的临床研究,2020/01/01-2022/12/31,10万。 (2)上海交通大学转化医学协同创新中心合作研究项目,TM202111,新型迷走神经脉冲射频术在化疗诱发的周围神经病变治疗中的应用,2021/11-2023/12, 10万。 2.重要论文 (1)Xu Y, Jiang Q, and Xu X. The Tourniquet Ischemia Test Effectively Predicts the Efficacy of Lumbar Sympathetic Block in Patients with Lower Extremity Complex Regional Pain Syndrome Type 1. J Pain Res. 2022, 15: 1659-1667(第一作者) (2)Xu Y, Zhu Y, Yue Y, Pu S, Wu J, Lv Y, and Du D. Tamoxifen attenuates reactive astrocyte-induced brain metastasis and drug resistance through the IL-6/STAT3 signaling pathway. Acta Biochim Biophys Sin 2020, 52: 1299-1305(第一作者) (3)Wang H, Huang M, Wang W, Zhang Y, Ma X, Luo L, Xu X, et al. Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance. Pharmacol Res 2021, 165: 105482(共同通讯) (4)Xu Y, Cheng G, Zhu Y, Zhang X, Pu S, Wu J, Lv Y, et al. Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain. Acta Biochim Biophys Sin 2016, 48: 902-908(第一作者) (5)Xu Y, Zhang X, Pu S, Wu J, Lv Y, and Du D. Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions. Acta Biochim Biophys Sin 2014, 46: 942-949(第一作者)