长期从事急诊及重症医学专科，擅长病毒性肺炎、脓毒症、严重多发伤、急性肺损伤、急性中毒等临床救治，主持国家自然基金及省部级研究项目10余项，主导及参与国内外多中心研究25项，发表论著近100篇，SCI34篇，总影响因子120分。获得2022年上海市医学科技奖一等奖。 1.Xie Y, Cao S, Dong H, et al. Effect of regular intravenous immunoglobulin therapy on prognosis of severe pneumonia in patients with COVID-19[J]. J Infect, 2020. 2020,81 (2): 318-356. 2.Prone positioning in high-flow nasal cannula for COVID-1 9 patients with sev ere hypoxemia: a pi lot study Ann Transl Med,2020 May；8（9）:598. 3.Zhang JX ,  Lu J , Xie H ,Wang RL circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA. Cell Death Dis.2019 Feb 22 ;10(3) :182. 4.Ren, L;Zhang, W;Han, P;Zhang, J;Zhu, Y;Meng, X;Zhang, J;Hu, Y;Yi, Z;Wang, R.Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxiainducible factor-1α via inhibition of proteasome. Virology.2019 Apr ;530 :51-58. 5.Yong Zhu, Jinfeng Wang, Xiaoxiao Meng, Jiuting Tan, Peng Han, Ruilan Wang. A positive feedback loop promotes HIF-1α stability through miR-210-mediated suppression of RUNX3 in paraquat-induced EMT. Journal of Cellular and Molecular Medicine. 2017 Jul 12(Epub ahead of print). 6.Yong Zhu, Guoying Deng, Anqi Ji, Jiayi Yao, Xiaoxiao Meng, Jingfeng Wang, Qian Wang, Qiugen Wang,Ruilan Wang.  Porous Se@SiO2 nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress. International Journal of Nanomedicine.2017:12 7143–7152. 7.Xinkun Guo, Zhaoqin Zhu, Wanju Zhang, Xiaoxiao Meng, Yong Zhu, Peng Han, Xiaohui Zhou, Yunwen Hu and Ruilan Wang. Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines. Emerging Microbes & Infections. 2017, 6(5): e39. 8.Zhu Y, Tan J, Xie H,et al. HIF-1α regulates EMT via the Snail and β-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis[J]. Journal of Cellular & Molecular Medicine, 2016, 20(4):688.