一、临床工作 ·临床上长期从事消化道肿瘤内镜下诊治（包括息肉电切、内镜下粘膜切除术及内镜粘膜下剥离术等），熟练掌握 NBI 技术及多种新型内镜成内像技术、分型诊断标准 ·连续举办19届全国性NBI培训班 ·主持3届国家继续教育项目《胃肠道早癌的内镜诊断与治疗》 ·主编专著三部：《消化内镜窄带显像技术临床应用图谱》（国内第一本NBI专著）以及第二版、《消化道早期癌放大内镜诊断手册》、《上消化道早癌内镜诊治病例解析》 二、科研项目与所获奖项 科研项目： ·上海市科委项目： 人工智能实时辅助内镜结直肠小息肉病理性质诊断系统的建立与验证（项目负责人） 内镜下超声穿刺针在间质瘤诊疗中的应用研究（项目负责人） LGR1在低氧诱导结肠癌细胞上皮-间充质转化中的作用机制（项目负责人） 基于内镜的胃癌早期诊断与微创治疗研究（参与） ·上海市卫生和计划生育委员会项目： PD-L2分子标志物结合激光共聚焦显微内镜用于结直肠癌肿瘤诊断的应用推广（项目负责人） ·上海仁济医院临床科研创新培育基金 胃癌窄带成像内镜早期诊断模型建立及多学科协作治疗模式研究（项目负责人） ·上海市教委项目： 结直肠平坦、凹陷型早期癌内镜诊治及分子机制研究（项目负责人） ·上海市卫生局局级课题： 急性胃肠道感染后功能性消化不良的临床特点及症状产生机制研究（项目负责人） ·横向课题： 含雷贝拉唑的四联疗法和高剂量二联疗法补救治疗Hp感染的作用（项目负责人） 替普瑞酮（施维舒）联合雷贝拉唑预防胃ESD术后出血的疗效比较（项目负责人） 雷贝拉唑按需治疗非糜烂性胃食管反流病的有效性和安全性研究（项目负责人） ·申康三年行动项目： 基于简易窄带成像分型的早期胃癌临床诊断模型的研究与推广（项目负责人） 沙利度胺治疗难治性消化道出血的随机安慰剂对照研究（参与） ·上海市教育委员会高峰高原学科建设计划： 胃肠道血管畸形所致消化道出血规范化治疗策略的研究及推广（参与） 所获奖励： 项目名称：胃肠癌预警、预防和发生中的新发现及其临床应用 奖励等级：国家科技进步二等奖（第六完成人） 所获专利： 《NBI简易分型诊断早期胃癌的管理软件V1.0》（2018SR908157） 三、论著发表 共发表论文135篇。其中第一/通讯作者（含共同）发表SCI 50篇，累积影响因子 203.34。 代表性论文： 1.Li, X. B. （第一作者）, J. Dai, H. M. Chen, J. Zhuang, Y. Song, Y. J. Gao and Z. Z. Ge. "A Novel Modality for the Estimation of the Enteroscope Insertion Depth During Double-Balloon Enteroscopy." Gastrointest Endosc 72, no. 5 (2010): 999-1005. 2.Xiao-Bo Li（第一作者）, Li-Yang Gu, Yan Song, et al. Small bowel perforation in a patient with Roux-en-Y anatomy for Peutz-Jeghers polyps after spiral enteroscopic investigation. Endoscopy, 2010, 42: E 3.Li, X. B. （第一作者）, L. Y. Gu, Y. Song, Y. J. Gao and Z. Z. Ge. "Small-Bowel Perforation in a Patient with Roux-En-Y Anatomy for Peutz-Jeghers Polyps after Spiral Enteroscopic Investigation." Endoscopy 43 Suppl 2 UCTN,  (2011): E85. 4.Li, X. （第一作者）, J. Dai, H. Lu, Y. Gao, H. Chen and Z. Ge. "A Prospective Study on Evaluating the Diagnostic Yield of Video Capsule Endoscopy Followed by Directed Double-Balloon Enteroscopy in Patients with Obscure Gastrointestinal Bleeding." Dig Dis Sci 55, no. 6 (2010): 1704-10. 【IF = 2.75】 5.Gu, L. Y., W. W. Lin, H. Lu, X. Y. Chen, Z. Z. Ge and X. B. Li.（通讯作者） "Quadruple Therapy with Medications Containing Either Rufloxacin or Furazolidone as a Rescue Regimen in the Treatment of Helicobacter Pylori-Infected Dyspepsia Patients: A Randomized Pilot Study." Helicobacter 16, no. 4 (2011): 284-8. 6.Li, H. Y., J. Dai, H. B. Xue, Y. J. Zhao, X. Y. Chen, Y. J. Gao, Y. Song, Z. Z. Ge and X. B. Li.（通讯作者） "Application of Magnifying Endoscopy with Narrow-Band Imaging in Diagnosing Gastric Lesions: A Prospective Study." Gastrointest Endosc 76, no. 6 (2012): 1124-32. 7.Zhu, L., X. Li（通讯作者）, Y. Chen, J. Fang and Z. Ge. "High-Mobility Group Box 1: A Novel Inducer of the Epithelial-Mesenchymal Transition in Colorectal Carcinoma." Cancer Lett 357, no. 2 (2015): 527-34. 8.Zhu, L., L. Ren, Y. Chen, J. Fang, Z. Ge and X. Li. （通讯作者） "Redox Status of High-Mobility Group Box 1 Performs a Dual Role in Angiogenesis of Colorectal Carcinoma." J Cell Mol Med 19, no. 9 (2015): 2128-35. 9.Zhou, Y., H. Y. Li, J. J. Zhang, X. Y. Chen, Z. Z. Ge and X. B. Li. （通讯作者） "Operative Link on Gastritis Assessment Stage Is an Appropriate Predictor of Early Gastric Cancer." World J Gastroenterol 22, no. 13 (2016): 3670-8. 10.Zhang, J., L. Zhu, J. Fang, Z. Ge and X. Li. （通讯作者） "Lrg1 Modulates Epithelial-Mesenchymal Transition and Angiogenesis in Colorectal Cancer Via Hif-1alpha Activation." J Exp Clin Cancer Res 35,  (2016): 29. 11.Zhang, Q. W., L. M. Teng, X. T. Zhang, J. J. Zhang, Y. Zhou, Z. R. Zhou, Y. C. Hou, Z. Z. Ge and X. B. Li. （通讯作者）"Narrow-Band Imaging in the Diagnosis of Deep Submucosal Colorectal Cancers: A Systematic Review and Meta-Analysis." Endoscopy 49, no. 6 (2017): 564-580. 12. Zhang QW, Zhang XT, Tang CT, Lin XL, Ge ZZ, Li XB（通讯作者）: EGFL6 promotes cell proliferation in colorectal cancer via regulation of the WNT/β-catenin pathway. Molecular carcinogenesis 2019, 58(6):967-979. 13.Chen JN, Zhang QW, Pan YB, Wang QW, Zhang XT, Li XB（通讯作者）: Young-Onset Early Colorectal Cancer Had Similar Relative Survival to but Better Overall Survival Than Conventional Early Colorectal Cancer: A Large Population-Based Study. Front Oncol 2020;10:96. 14.Wang H, Chen B, Lin Y, Zhou Y, Li X（通讯作者）: Legumain Promotes Gastric Cancer Progression Through Tumor-associated Macrophages In vitro and In vivo. International journal of biological sciences 2020, 16(1):172-180. 15.Zhang QW, Zhang CH, Pan YB, Biondi A, Fico V, Persiani R, Wu S, Gao YJ, Chen HM, Shi OM, . . . Li XB（通讯作者）: Prognosis of colorectal cancer patients is associated with the novel log odds of positive lymph nodes scheme: derivation and external validation. J Cancer 2020, 11(7):1702-1711. 16.Zhou YJ, Zhu GQ, Lu XF, Zheng KI, Wang QW, Chen JN, Zhang QW, Yan FR, Li XB（通讯作者）: Identification and validation of tumour microenvironment-based immune molecular subgroups for gastric cancer: immunotherapeutic implications. Cancer immunology, immunotherapy 2020 Jun;69(6):1057-1069. 17.Chen JN, Wang QW, Zhang QW, . . . Li XB（通讯作者）: Poorly differentiated is more significant than signet ring cell component for lymph node metastasis in mixed-type early gastric cancer: a retrospective study from a large-volume hospital. Surg Endosc (2020). 18.Zhang QW, Zhang Z, Xu J, Dai ZH, Zhao R, Huang J, Qiu H, Tang ZR, Niu B, Zhang XB, Wang PF, Yang M, Deng WY, Lin YS, Xiang S, Ge ZZ, Qian D, Li XB（通讯作者）. Multi-step validation of a deep learning-based system with visual explanations for optical diagnosis of polyps with advanced features. iScience. 2024 Mar 8;27(4):109461. 19.Xie Z, Suo S, Zhang W, Zhang Q, Dai Y, Song Y, Li X（通讯作者）, Zhou Y. Prediction of high Ki-67 proliferation index of gastrointestinal stromal tumors based on CT at non-contrast-enhanced and different contrast-enhanced phases. Eur Radiol. 2024 Apr;34(4):2223-2232. doi: 10.1007/s00330-023-10249-3. Epub 2023 Sep 29. 20.Ning L, Wang X, Xuan B, Ma Y, Yan Y, Gao Z, Tong T, Cui Z, Chen H, Li X（通讯作者）, Hong J, Wang Z. Identification and investigation of depression-related molecular subtypes in inflammatory bowel disease and the anti-inflammatory mechanisms of paroxetine. Front Immunol. 2023 Feb 27;14:1145070. 21.Yu M, Ding H, Gong S, Luo Y, Lin H, Mu Y, Li H, Li X（通讯作者）, Zhong M. Fungal dysbiosis facilitates inflammatory bowel disease by enhancing CD4+ T cell glutaminolysis. Front Cell Infect Microbiol. 2023 Apr 14;13:1140757. 22.Wang XY, Zhou YJ, Chen HY, Chen JN, Chen SS, Chen HM, Li XB（通讯作者）. 5'tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer. World J Gastrointest Oncol. 2023 Jun 15;15(6):1005-1018. 23.Zhang QW, Zhang RY, Yan ZB, Zhao YX, Wang XY, Jin JZ, Qiu QX, Chen JJ, Xie ZH, Lin J, Cao H, Zhou Y, Chen HM, Li XB（通讯作者）. Personalized radiomics signature to screen for KIT-11 mutation genotypes among patients with gastrointestinal stromal tumors: a retrospective multicenter study. J Transl Med. 2023 Oct 16;21(1):726. 24.Wang X, Zhou Y, Ning L, Chen J, Chen H, Li X（通讯作者）. Publisher Correction: Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer. Cell Death Dis. 2023 Oct 16;14(10):683. 25.Huang Y, Chen J, Guo Y, Ding Z, Liang X, Zhang W, Xue H, Zhao Y, Li X（通讯作者）, Lu H. Staging of operative link on gastritis assessment and operative link on gastric intestinal metaplasia systems for risk assessment of early gastric cancer: a case-control study. J Clin Pathol. 2023 Nov 21:jcp-2023-209209.