科研项目 1. 国家自然科学基金委员会, 面上项目, 8187110182, 基于特异性多肽 CBP-DWS 靶向化疗 结肠癌的基础研究, 2019-01 至 2022-12, 57 万元； 2. 上海市科学技术委员会， 重点项目，14140901900，诱导型原发性肝癌基因敲除斑马鱼模 型及小鼠模型的建立，2014-07 至 2016-09，40 万元； 3. 国家自然科学基金委员会，面上项目，81272745，LKB1/AMPK 调控有氧酵解信号途径诱 导结肠癌细胞凋亡机制的研究，2013-01 至 2016-12，70 万元； 4. 国家自然科学基金委员会，面上项目，81072007，TRB3 对肝癌细胞凋亡的影响及其机理 的研究，2011-01 至 2013-12，33 万元. 5. 上海市高地大项目（3年，每年200万）； 6. 上海交通大学医工交叉重点项目（2024年）50万； 专利申请 1. 实用新型专利：发明人 孟祥军.一种经皮胃造瘘口胃内气囊置入装置 （ZL 2017 2 0985035.4）； 2. 发明专利：发明人 孟祥军、田晓慧、侯利丹、祝丹希、梁钰、王建华. 人结肠癌细胞特 异性结合多肽的筛选方法及其应用 （L 2017 1 0183340.6）； 3. 实用新型专利：发明人 李雷、侯利丹、侯一超、庞文璟、孟祥军. 内窥镜用管状附件及 内窥镜套件：（ZL 2022 2 0312129.6）; 4. 实用新型专利：发明人 陈慧瑛、许菁菁、孟祥军、侯利丹、霍立. 胃造瘘管体外固定装 置 （ZL 2021 2 1113414.7） 2 项正在转化过程中 代表性论文 1. Hou Yichao#, Zhang Xintian#, Yao Han#, Hou Lidan, Zhang Qingwei, Tao Enwei, Zhu Xiaoqiang, Jiang Shanshan, Ren Yimeng, Hong Xialu, Lu Shiyuan, Leng Xiaoxu, Xie Yile, Gao Yaqi, Liang Yu, Zhong Ting, Long Bohan, Fang Jingyuan*, Meng Xiangjun*. METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells. EMBO Reports. 2023 Apr 5; 24(4) 2. Lidan Hou , Ting Zhong , Peng Cheng , Bohan Long , Leilei Shi , Xiangjun Meng , Han Yao* Selfassembled peptide-paclitaxel nanoparticles for enhancing therapeutic efficacy in colorectal cancer. Front Bioeng Biotechnol. 2022; 10: 938662. 3. Hou Lidan#, Hou Yichao#, Liang Yu#, Chen Baiyu, Zhang Xintian, Wang Yu, Zhou Kun, Zhong Ting, Long Bohan, Pang Wenjing, Wang Lei, Han Xu, Li Linjing, Xu Ci, Gross Isabelle, Gaiddon Christian, Fu Wei*, Yao Han*, Meng Xiangjun*. Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer. Communications Biology. 2022 Nov 14; 5(1):1248. 4. Hou Yichao#, Zhang Qingwei#, Pang Wenjing, Hou Lidan, Liang Yu, Han Xu, Luo Xiaoyu, Wang Ping, Zhang Xintian, Li Lei*, Meng Xiangjun*. YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect. Cell death and differentiation 2021 May 21. 5. Wang Lei, Pang Wenjing, Zhou Kun, Li Lei, Wang Feng, Cao Wei, Meng XiangJun * Risk Factors for Esophageal Squamous Cell Carcinoma in Patients with Head and Neck Squamous Cell Carcinoma. Oncology. 2022 Aug 27; 2022: 5227771 6. Pang Wenjing, Yao Weiyan, Dai Xin, Zhang Aisen, Hou Lidan, Wang Lei, Wang Yu, Huang Xin, Meng Xiangjun*, Li Lei*. Pancreatic cancer-derived exosomal microRNA-19a induces β-cell dysfunction by targeting ADCY1 and EPAC2. International Journal of Biological Science. 2021 Aug 21; 17(13):3622-3633 7. Shi Leilei, Wu Wenbo, Duan Yukun, Xu Li, Xu Yingying, Hou Lidan, Meng Xiangjun, Zhu Xinyuan, Liu Bin*. Light-Induced Self-Escape of Spherical Nucleic Acid from Endo/Lysosome for Efficient Non-Cationic Gene Delivery. Angew Chem Int Ed Engl. 2020 Oct 19; 59(43):19168-19174. 8. Zhou Kun, Cao Dachun, Wang Yu, Wang Lei, Meng Xiangjun*. Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2. Aging (Albany NY). 2021 Jun 28; 13(12):16763-16772 9. Shi L, Hu Fang, Duan Yukun, Wu Wenbo, Dong Jinqiao, Meng Xiangjun, Zhu Xinyuan, Liu Bin*. Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy. ACS Nano. 2020 Feb 25; 14(2):2183-2190 10. Wang Lei, Pang Wenjing, Zhou Kun, Li Lei, Wang Feng, Cao Wei*, Meng Xiangjun*. Characteristics of esophageal cancer in patients with head and neck squamous cell carcinoma. Translational Cancer Research. 2021 May; 10(5):1954-1961. 11. Wu Wenbo, Shi Leilei, Duan Yukun, Xu Shidang, Shen Lingyue, Zhu Ting, Hou Lidan, Meng Xiangjun, Liu Bin*. Nanobody modified high-performance AIE photosensitizer nanoparticles for precise photodynamic oral cancer therapy of patient-derived tumor xenograft. Biomaterials. 2021 Jul; 274:120870. 12. Cheng Peng, Chen Qingqi, Li Juyuan, Pang Li, Feng Caituan, Wang Ning, Bai Yu, Li  Zhaoshen*, Meng Xiangjun*. 3 liters of polyethylene glycol vs. standard bowel preparation have equal efficacy in a Chinese population: a randomized, controlled trial. American Journal ofTranslational Research. 2022 Aug 15; 14(8):5641-5650. 13. Cheng Peng, Ma Ruijun, Wang Shuling, Fang Jun, Zhong Zhengrong, Bai Yu, Meng Xiangjun*, Li Zhaoshen*. Effect of the High-FODMAP Diet on Bowel Preparation for Colonoscopy: A Multicenter, Prospective Cohort Study. Gastroenterology Research and Practice. 2020 Jun 22;2020:1612040 14. Liang Yu#; Hou Lidan#; Li Linjing; Li Lei; Zhu Liming; Wang Yu; Huang Xin; Hou Yichao; Zhu Danxi; Zou Huimin; Gu Yan; Weng Xiaoling; Wang Yingying; Li Yue; Wu Tianqi; Yao Mengfei; Gross Isabelle; Gaiddon Christian; Luo Meng*; Wang Jianhua*; Meng Xiangjun*.  Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway. Oncogene 2020, 39 (2), 469-485. 15. Huang Xin#; Hou Yichao#; Weng Xiaoling; Pang Wenjing; Hou Lidan; Liang Yu; Wang Yu; Du Leilei; Wu Tianqi; Yao Mengfei; Wang Jianhua*; Meng Xiangjun*.  Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway. Oncogenesis, 2021. 10(1): 4. 16. Hou Yichao#; Hou Lidan#; Liang Yu#; Zhang Qingwei; Hong Xialu; Wang Yu; Huang Xin; Zhong Ting; Pang Wenjing; Xu Ci; Zhu Liming; Li Lei; Fang Jingyuan*; Meng Xiangjun*. The p53-inducible CLDN7 regulates colorectal tumorigenesis and has prognostic significance. Neoplasia, 2020. 22(11): 590-603. 17. Wang Yu#; Zhu Liming#; Guo mei#; Sun Gang; Zhou Kun; Pang Wenjing; Cao Dachun*; Tang Xin*; Meng Xiangjun*. Histone methyltransferase WHSC1 inhibits colorectal cancer cell apoptosis via targeting anti-apoptotic BCL2. Cell Death Discovery, 2021. 7(1): 19. 18. Liang Yu#; Zhu Danxi#; Hou Lidan#; Wang Yu; Huang Xin; Zhou Cui; Zhu Liming; Wang Yingying; Li Lei; Gu Yan; Luo Meng; Wang Jianhua*; Meng Xiangjun*. MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. British Journal of Cancer, 2020. 122(5): 705-714. 19. Liang Yu#; Zhu Danxi#; Zhu Liming; Hou Yichao; Hou Lidan; Huang Xin; Li Linjing; Wang Yu; Li Lei;Zou Huimin; Wu Tianqi; Yao Mengfei; Wang Jianhua*; Meng Xiangjun*. Dichloroacetate Overcomes Oxaliplatin Chemoresistance in Colorectal Cancer through the miR543/PTEN/Akt/mTOR Pathway. Journal of Cancer 2019, 10 (24), 6037-6047. 20. Lidan Hou#; Danxi Zhu#; Yu Liang; Xiaohui Tian; Lei Li; Ping Wang;Liming Zhu; Xiaoling Weng; Yingying Wang; Yue Li; Tianqi Wu;Jianhua Wang*; Xiangjun Meng*. Identification of a specific peptide binding to colon cancer cells from a phage-displayed peptide library. British Journal of Cancer, 2018.1,118(1): 79-87. 21. Luo Xiaoyu; Xiangjun Meng*; Dachun Cao*; Wei Wang; Kun Zhou; Lei Li; Mei Guo; Ping Wang. Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes. Stem Cell Research & Therapy, 2019. 10(1): 16. 22. Wang Yingying; Weng Xiaoling; Wang Luoyang; Hao Mingang; Li Yue; Hou Lidan; Liang Yu; Wu Tianqi; Yao Mengfei; Lin Guowen; Jiang Yiwei; FuGuohui; Hou Zhaoyuan*; Meng Xiangjun*; Lu Jinsong*; Wang Jianhua*, HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk. The Journal of Clinical Investigation 2018, 128 (12), 5235-5250. 23. Leilei Shi; Fang Hu; Yukun Duan; Wenbo Wu; Jinqiao Dong; Xiangjun Meng; Xinyuan Zhu; Bin Liu. Hybrid Nanospheres to Overcome Hypoxia and Intrinsic Oxidative Resistance for Enhanced Photodynamic Therapy. ACS Nano, 2020. 14(2): 2183-2190. 24. Mingang Hao#; Xiaoling Weng#; Yingying Wang; Xueqin Sun; Tingting Yan; Yu Li; Lidan Hou; Xiangjun Meng*; Jianhua Wang*. Targeting CXCR7 improves the efficacy of breast cancer patients with tamoxifen therapy. Biochemical Pharmacology, 2018. 147: 128-140. 25. Li Yang, Zhu Danxi, Hou Lidan, Hu Bin; Xu Min; Meng Xiangjun*. TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells. Oncology Letters. 2018 Jan;15(1):1343-1349. 26. Zhu Danxi#; Hou Lidan#; Hu Bin; Zhao Hang; Sun Jie; Wang Jianhua; Meng Xiangjun*. Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated withsodium dichloroacetate. Scientific Reports,2016.11.22. 27. Zhao Hang#; He Zhiying#; Huang Dandan; Gao Jun; Gong Yanfang; Wu Hongyu; Xu Aifang; Meng Xiangjun*; Li Zhaoshen*. Infusion of Bone Marrow Mesenchymal Stem Cells Attenuates Experimental Severe Acute Pancreatitis in Rats. Stem Cells International, 2016. 2016: 7174319. 28. Hu Bin#; Tian Xiaohui#; Sun Jie; Meng Xiangjun*. Evaluation of individual and combined applications of serum biomarkers for diagnosis of hepatocellular carcinoma: a meta-analysis International Journal of Molecular Science, 2013. 14(12): 23559-23580. 29. Xu Xiaowei; Li Baiwen; Huang Peijie; Wan Xinjian; Qin Youwen; Zhou Lili; Liu Huixia; Bai Haitao; Gao Yanrong; Wang Chun; Meng Xiangjun*. Citrate induces apoptosis of the acute monocytic leukemia U937 cell line through regulation of HIF-1alpha signaling. Molecular Medicine Report, 2013. 8(5): 1379-1384. 30. Li Baiwen; Wan Xinjian; Zhu Qi; Li Lei; Zeng Yue; Hu Duanmin; Qian Yueqin; Lu Lungen; Wang Xingpeng*; Meng Xiangjun*. Net expression inhibits the growth of pancreatic ductal adenocarcinoma cell PL45 in vitro and in vivo. PLoS One, 2013. 8(2): e57818. 31. Vidimar Vania#; Meng Xiangjun#; Klajner Marcelina#; Licona Cynthia; Fetzer Ludivine; Harlepp Sebastien; Hebraud Pascal; Sidhoum Marjorie; Sirlin Claude; Loeffler Jean-Philippe; Mellitzer Georg; Sava Gianni; Pfeffer Michel; Gaiddon Christian*. Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity. Biochemical Pharmacology, 2012. 84(11): 1428-1436. 32. Benosman Samir#; Meng Xiangjun#; Von Grabowiecki, Yannick; Palamiuc Lavinia; Hritcu Lucian; Gross Isabelle; Mellitzer Georg; Taya Yoichi; Loeffler Jean-Philippe; Gaiddon Christian*. Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons. Journal of Biological Chemistry, 2011. 286(50): 43013-43025. 33. Meng Xiangjun#; Leyva Mili L.#; Jenny Marjorie; Gross Isabelle; Benosman Samir; Fricker Bastien; Harlepp Sebastien; Hebraud Pascal; Boos Anne; Wlosik Pauline; Bischoff Pierre; Sirlin Claude; Pfeffer Michel; Loeffler Jean-Philippe; Gaiddon Christian. A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Research, 2009. 69(13): 5458-5466. 34. Arup Kumar Indra 1, Eduardo Castaneda, Maria Cristina Antal, Ming Jiang, Nadia Messaddeq, Xiangjun Meng, Christiane V Loehr, Patricio Gariglio, Shigeaki Kato, Walter Wahli, Béatrice Desvergne, Daniel Metzger*, Pierre Chambon* Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. The Journal of Investigative Dermatology 2007 May;127(5):1250-60. 35. Chandrahas Koumar Ratnacaram1, Marius Teletin, Ming Jiang, Xiangjun Meng, Pierre Chambon*, Daniel Metzger* Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2521-6. 36. Ludivine Fetzer 1, Bastien Boff, Moussa Ali, Meng Xiangjun, Jean-Paul Collin, Claude Sirlin, Christian Gaiddon*, Michel Pfeffer* Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier. Dalton Transactions. 2011