从事内耳疾病及阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床与应用基础研究三十余年，在聋病诊治领域，在国内率先开展耳道上径路耳蜗植入，CO2激光辅助一次成形人工镫骨置换、锤骨前庭假体技术，倡导早期人工耳蜗植入，完成多种复杂疑难病例的人工耳蜗植入，研究成果获得上-市科技进步一等奖（2013，01）、上海医学科技二等奖（2012，01）；在耳源性眩晕诊治领域，开创性地将半规管阻塞技术运用于水平半规管BPPV、胆脂瘤迷路瘘管、难治性梅尼埃病等多种难治性眩晕的外科治疗，获得上海医学科技奖三等奖（2003，01）、教育部科技进步奖二等奖（2008?2）、中华医学科技进步奖一等奖（2008，02）、上海市科技进步奖二等奖（2009，01）；在鼾症诊治领域，建立了大样本鼾症人群队列，系统评估各种外科治疗方法的有效性及预后指标，提出鼾症外科治疗个性化策略，在国内率先开展双颌前徙等系列外科技术治疗重度鼾症，并依据国人厥萁懈牧迹竦蒙虾Ｒ窖Э萍冀比冉保?006，01）、上海市科技进步奖三等奖（2007，01）。专注于聋病、眩晕及鼾症等疾病的临床及基础研究，先后主持国家级、省部级科研课题数十项，其中包括国家自然基金杰出青年基金项目、重点项目，973子课题，卫生部重大行业基金子课题各1项。在SCI收录期刊发表论文127篇。
1.Hengchao Chen(#),Yazhi Xing, Li Xia, Zhengnong Chen, Shankai Yin(*), Jian Wang(*).AAV-mediated NT-3 overexpression protects cochleae against noise-induced synaptopathy.Gene Ther. 2018; 25(4): 251–259.Published online 2018 Mar 13. doi:  [10.1038/s41434-018-0012-0].
2.JuanjuanZou(#),YunyanXia(#),HuajunXu(#),YiqunFu,YingjunQian,XinyiLi,XiaolongZhao,JianyinZou,LiliMeng,SuruLiu,HuamingZhu,HongliangYi,JianGuan(*),BinChen(*),ShankaiYin(*).Independent relationships between cardinal features of obstructive sleep apnea and glycometabolism: a cross-sectional study.Metabolism Volume 85, August 2018, Pages 340-347.IF:5.963
3.Liang, Min(#),Yin, Xin-Lu(#),Wang, Lu-Yang,Yin, Wei-Hai,Song,Ning-Ying,Shi, Hai-Bo(*),Li, Chun-Yan(*),Yin, Shan-Kai(*).NAD+ Attenuates Bilirubin-Induced Hyperexcitation in the Ventral Cochlear Nucleus by Inhibiting Excitatory Neurotransmission and Neuronal Excitability.Front Cell Neurosci,2017,01.01,11:21.IF:4.3
4.Guan, Jian(#),Yi, Hongliang,Zou, Jianyin,Meng, Lili,Tang, Xulan,Zhu, Huaming,Yu, Dongzhen,Zhou, Huiqun,Su, Kaiming,Yang, Mingpo,Chen,Haoyan,Shi, Yongyong,Wang, Yue,Wang, Jian,Yin, Shankai(*).Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study.Thorax.?2016 Apr;71(4):347-55. doi: 10.1136/thoraxjnl-2015-207403. Epub 2016 Feb 16.IF:8.272.引用次数：12
5.Song, Qiang(#),Shen, Pei，Li, Xiaowei，Shi, Lijuan，Liu, Lijie，Wang,Jiping，Yu, Zhiping，Stephen, Kegan，Aiken, Steve，Yin, Shankai(*)，Wang, Jian(*) .Coding deficits in hidden hearing loss induced by noise: the nature and impacts.Sci Rep. 2016 Apr 27;6:25200. doi: 10.1038/srep25200.IF:4.259.
6.Xu, Yanan(#),Zheng, Xiaojiao,Qiu, Yunping,Jia, Wei,Wang, Jiadong(*),Yin, Shankai(*).Distinct Metabolomic Profiles of Papillary Thyroid Carcinoma and Benign Thyroid Adenoma.Journal of Proteome Research，2015.8.7,14（8）:315~3321.IF:4.173.
7.Xu, Huajun(#),Yi, Hongliang,Guan, Jian(*),Yin, Shankai(*).Effect of continuous positive airway pressure on lipid profile in patients with obstructive sleep apnea syndrome： A meta-analysis of randomized controlled trials.Atherosclerosis，2014.6.01,234（2）:446~453.IF:3.994.
8.Chen, Zhengnong(#),Prasad, Sampath Chandra,Di Lella, Filippo,Medina, Marimar，Piccirillo, Enrico，Taibah, Abdelkader，Russo, Alessandra,Yin,Shankai(*),Sanna, Mario.The behavior of residual tumors and facial nerve outcomes after incomplete excision of vestibular schwannomas Clinical article.Journal of Neurosurgery,2014.6.01,120（6）:1278~1287.IF:3.737.
9.Lijie Liu(#),Hui Wang(#),Lijuan Shi(#),Awad Almuklass(#),Tingting He,Steve Aiken,Manohar Bance,Shankai Yin(*),Jian Wang(*).Silent Damage of Noise on Cochlear Afferent Innervation in Guinea Pigs and the Impact on Temporal Processing.PLoS One.2012;7(11):e49550.doi:10.1371/journal.pone.0049550. Epub 2012 Nov 21.IF:3.234.
10.Li, Chun-Yan(#),Shi, Hai-Bo(*),Ye, Hai-Bo,Song, Ning-ying,Yin,Shan-Kai(*).Minocycline cannot protect neurons against bilirubin-induced hyperexcitation in the ventral cochlear nucleus.Experimental Neurology,2012.9.01,237（1）:96~102.IF:4.645.
专利：
1、一种CT头颅定位架 实用新型专利 ZL 2013 2 0491390.8 发明人：易红良；殷善开；关建；张玉君；刘素茹；刘玉璞g周建荣
2、一种改进型斑马鱼听功能检测水箱 ZL 2015 2 0131119.2 发明人：殷善开；王坚；周建荣；王际平；夏力；于栋祯