基金与项目 1. 国家自然科学基金：81272917FoxM1调控TGF-β1/Smad信号通路促进乳腺癌EMT机制研究。 课题负责人60万2013.01-2016.12 2. 国家自然科学基金：81172022KLF4调控uPAR在肝细胞癌发生上皮－间质转化中的作用和机制研究 课题负责人55万2012.01-2015.12 3. 国家自然科学基金：81472576KLF4通过HNF-6信号通路影响肝癌细胞分化的机制研究。 课题负责人72万2015.01-2018.12 4. 国家自然科学基金：81772567 RNA编辑酶ADAR1调控PARP1在胃癌细胞化疗耐药中的作用及机制研究。课题负责人55万2017.01-2020.12 5. 国家自然科学基金：81972290 METTL14通过m6A修饰调控ADAR1促进结直肠癌发生和干性维持的机制研究。课题负责人55万，2019.1-2022.12 获奖与成果 1. 黑色素抑制因子CD-RAP的基础与临床研究，中国人民解放军，军队科技进步奖，二等奖，2003 2. 靶向抑制转录因子Sp1逆转胃癌抗血管治疗耐药的基础研究及应用，上海市医学科技奖，三等奖，2013 Publications : 1. Xiaodan Chong, Jingde Chen, Nanxin Zheng, Zhuqing Zhou, Yanan Hai, Shiqing Chen, Yu Zhang, Qingzhuo Yu, Shijun Yu, Zhiqin Chen, Wenfang Bao, Ming Quan, Zhe-Sheng Chen, Yangyang Zhan, Yong Gao. PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. Mol Cancer. 2022 May 26;21(1):118(IF=44.1) 2. Zhiqin Chen, Jinde Chen, Yong Gao, Ming Quan. Heterogeneous clinical and pathological landscapes of HER2 positive colorectal cancer. Expert Rev Anticancer Ther. 2021 Oct;21(10):1097-1104.(IF=4.51) 3. Zhiqin Chen, Haifei Song, Xiaochen Zeng, Ming Quan, Yong Gao. Screening and discrimination of optimal prognostic genes for pancreatic cancer based on a prognostic prediction model. G3 (Bethesda). 2021 Oct 19;11(11).(IF=3.15) 4. Shijun Yu, Qingqing Hu, Kailing Fan, Chen Yang, Yong Gao. CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling. J Cell Commun Signal. 2021 Sep;15(3):383-392.(IF=5.78) 5. Yu S, Li L, Fan K, Li Y, Gao Y. A Genome-Scale CRISPR Knock-Out Screen Identifies MicroRNA-5197-5p as a Promising Radiosensitive Biomarker in Colorectal Cancer.Front Oncol.2021 Jul 30;11:696713.IF:6.244 6. Chen Z, Chen J, Gao Y, Quan M. Heterogeneous clinical and pathological landscapes of HER2 positive colorectal cancer.Expert Rev Anticancer Ther. 2021 Jul 14;1-8.IF:4.513 7. Liu X, Zhou P, He K, Wen Z, Gao Y. Dioscorea Zingiberensis New Saponin Inhibits the Growth of Hepatocellular Carcinoma by Suppressing the Expression of Long Non-coding RNA TCONS-00026762.Front Pharmacol. 2021 May 3;12:678620.IF:5.81 8. Li L, Tao X, Li Y, Gao Y, Li Q. CDC37L1 acts as a suppressor of migration and proliferation in gastric cancer by down-regulating CDK6. J Cancer.2021 Mar 31;12(11):3145-3153.IF:4.2 9. Yu S, Hu Q, Fan K, Yang C, Gao Y. CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling.J Cell Commun Signal.2021 Sep;15(3):383-392.IF:5.78 10. Wang X, Dou N, Wang J, Zhang Y, Li Y, Gao Y.FOXM1-induced miR-552 expression contributes to pancreatic cancer progression by targeting multiple tumor suppressor genes.Int J Biol Sci.2021 Mar 1;17(4):915-925.IF:6.584 11. Yu S, Li L, Cai H, He B, Gao Y, Li Y. Overexpression of NELFE contributes to gastric cancer progression via Wnt/β-catenin signaling-mediated activation of CSNK2B expression.J Exp Clin Cancer Res.2021 Feb 1;40(1):54.IF:11.16 12. Xie D, Yu S, Li L, Quan M, Gao Y. The FOXM1/ATX signaling contributes to pancreatic cancer development..Am J Transl Res. 2020 Aug 15;12(8):4478-4487. eCollection 2020.IF:4.063 13. Dou N, Hu Q, Li L, Wu Q, Li Y, Gao Y.USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.Int J Biol Sci. 2020 Mar 12;16(9):1648-1657.IF:6.58 14. Shijun Yu, Jingde Chen, Ming Quan, Li Li, Yandong Li, Yong Gao. CD63 negatively regulates hepatocellular carcinoma development through suppression of inflammatory cytokine-induced STAT3 activation.J Cell Mol Med. 2020 Dec 4;25(2):1024-1034.IF:5.31 15. Chen J, Quan M, Chen Z, Zeng T, Li Y, Zhou Y, Hai Y, Gao Y.Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial. J Cancer Res Clin Oncol. 2020 Oct;146(10):2651-2657 IF:3.656 16. Yandong Li, Shijun Yu, Li Li, Jingde Chen, Ming Quan, Qinchuan Li, Yong Gao.KLF4-mediated upregulation of CD9 and CD81 suppresses hepatocellular carcinoma development via JNK signaling.Cell Death Dis. 2020 Apr 29;11(4):299.IF:8.464 17. Zhou C, Wei Z, Zhang Z, Zhang B, Zhu C, Chen K, Chuai G, Qu S, Xie L, Gao Y, Liu Q. pTuneos: prioritizing tumor neoantigens from next-generation sequencing data.Genome Med. 2019 Oct 30;11(1):67.IF:11.11 18. Li Li, Shijun Yu, Qiong Wu, Ning Dou, Yandong Li, Yong Gao. KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling. Int J Biol Sci. 2019 Mar 10;15(5):953-961.IF:4.858 19. Yu S, Gautam N, Quan M, Gao Y. RSRC1 suppresses gastric cancer cell proliferation and migration by regulating PTEN expression. Mol Med Rep. 2019 Aug;20(2):1747-1753. IF：2.1 20. Li Y, Yu S, Wang X, Ye X, He B, Quan M, Gao Y. SRPK1 facilitates tumor cell growth via modulating the small nucleolar RNA expression in gastric cancer. J Cell Physiol. 2019 Aug;234(8):13582-13591. IF：5.546 21. Yu S, Wang X, Dou N, Zhou J, Gao Y, Li Y. B-cell lymphoma-2-associated transcription factor 1 is overexpressed and contributes to sorafenib resistance in hepatocellular carcinoma. Hepatol Res. 2019 Nov;49(11):1329-1340 IF：3.165 22. Li L, Yu S, Wu Q, Dou N, Li Y, Gao Y. KLF4-Mediated CDH3 Upregulation Suppresses Human Hepatoma Cell Growth and Migration via GSK-3β Signaling. Int J Biol Sci. 2019;15(5):953-961. IF：4.858 23. Chen J, Li L, Zhou Z, Yu S, Li Y, Gao Y. FAPP2 promotes tumor cell growth in human colon cancer through activation of Wnt signaling. Exp Cell Res. 2019 Jan 1;374(1):12-18. IF：3.383 24. Dou N, Yang D, Yu S, Wu B, Gao Y, Li Y. SNRPA enhances tumour cell growth in gastric cancer through modulating NGF expression. Cell Prolif. 2018 Oct;51(5):e12484. IF：5.753 25. Yu S, Li L, Wu Q, Dou N, Li Y, Gao Y. PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes gastric cancer growth and metastasis via mechanistic target of rapamycin activation. Int J Oncol. 2018 Jun;52(6):2011-2020. IF：3.899 26. Zhang Y, Ye X, Chen L, Wu Q, Gao Y, Li Y. PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development. Int J Biol Sci. 2018;14(5):531-541. IF：4.858 27. Wu Q, Yu S, Chen J, Li Y, Gao Y. Downregulation of STRAP promotes tumor growth and metastasis in hepatocellular carcinoma via reducing PTEN level. IUBMB Life. 2018 Feb;70(2):120-128. IF：3.244 28. Wang Y, Jiang J, Li Q, Ma H, Xu Z, Gao Y. KAP1 is overexpressed in hepatocellular carcinoma and its clinical significance. Int J Clin Oncol. 2016 Oct;21(5):927-933. doi: 10.1007/s10147-016-0979-8. Epub 2016 Apr 19. PubMed PMID: 27095111. 29. Wang X, He B, Gao Y, Li Y. FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma. Tumour Biol. 2016 Aug;37(8):10459-67. doi: 10.1007/s13277-016-4923-3. Epub 2016 Feb 5. PubMed PMID: 26846213. 30. Ye X, Zhang Y, Wang X, Li Y, Gao Y. Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer. IUBMB Life. 2016 Apr;68(4):320-7. doi: 10.1002/iub.1486. Epub 2016 Mar 7. PubMed PMID: 26949059. 31. Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016 Apr;415(1-2):197-205. doi: 10.1007/s11010-016-2692-3. Epub 2016 Mar 21. PubMed PMID: 27000860. 32. Li Q, Li Y, Wang Y, Cui Z, Gong L, Qu Z, Zhong Y, Zhou J, Zhou Y, Gao Y, Li Y. Quantitative proteomic study of human prostate cancer cells with different metastatic potentials. Int J Oncol. 2016 Apr;48(4):1437-46. doi: 10.3892/ijo.2016.3378. Epub 2016 Feb 4. PubMed PMID: 26846621. 33. Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. Int J Clin Exp Pathol. 2015;8(12):15836-44. eCollection 2015. PubMed PMID: 26884854; PubMed Central PMCID: PMC4730067. 34. Li Y, Lin Y, Li Q, Gao Y. SRrp35 suppresses cell proliferation and malignancy in hepatocellular carcinoma. Hepatol Res. 2015 Dec;45(12):1241-7. doi: 10.1111/hepr.12493. Epub 2015 Mar 17. PubMed PMID: 25594558. 35. Chen Y, Cha Z, Fang W, Qian B, Yu W, Li W, Yu G, Gao Y. The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Oncotarget. 2015 Aug 21;6(24):20419-33. doi: 10.18632/oncotarget.3983. PubMed PMID: 25971332; PubMed Central PMCID: PMC4653015. 36. Feng C, Li X, Dong C, Zhang X, Zhang X, Gao Y. RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer. Drug Des Devel Ther. 2015;9:4613-20. doi: 10.2147/DDDT.S85993. eCollection 2015. PubMed PMID: 26316700; PubMed Central PMCID: PMC4541546. 37. Cai H, Chen J, He B, Li Q, Li Y, Gao Y. A FOXM1 related long non-coding RNA contributes to gastric cancer cell migration. Mol Cell Biochem. 2015 Aug;406(1-2):31-41. doi: 10.1007/s11010-015-2421-3. Epub 2015 Apr 24. PubMed PMID: 25907137. 38. Cai H, Ye X, He B, Li Q, Li Y, Gao Y. LncRNA-AP001631.9 promotes cell migration in gastric cancer. Int J Clin Exp Pathol. 2015;8(6):6235-44. eCollection 2015. PubMed PMID: 26261500; PubMed Central PMCID: PMC4525834. 39. Chen J, Jiang H, Wu Y, Li Y, Gao Y. A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation. Drug Des Devel Ther. 2015;9:2265-75. doi: 10.2147/DDDT.S81722. eCollection 2015. PubMed PMID: 25945038; PubMed Central PMCID: PMC4408971. 40. Wang Y, Wang Q, Zhang N, Ma H, Gu Y, Tang H, Xu Z, Gao Y. Identification of microRNAs as novel biomarkers for detecting esophageal squamous cell carcinoma in Asians: a meta-analysis. Tumour Biol. 2014 Nov;35(11):11595-604. doi: 10.1007/s13277-014-2350-x. Epub 2014 Aug 19. PubMed PMID: 25135426. 41. Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res. 2014 Aug 15;20(16):4370-80. doi: 10.1158/1078-0432.CCR-14-0186. Epub 2014 Jun 19. PubMed PMID: 24947925; PubMed Central PMCID: PMC4134726. 42. Li Q, Tian Y, Li D, Sun J, Shi D, Fang L, Gao Y, Liu H. The effect of lipocisplatin on cisplatin efficacy and nephrotoxicity in malignant breast cancer treatment. Biomaterials. 2014 Aug;35(24):6462-72. doi: 10.1016/j.biomaterials.2014.04.023. Epub 2014 May 3. PubMed PMID: 24797881. 43. Li Q, Wang H, Yu L, Zhou J, Chen J, Zhang X, Chen L, Gao Y, Li Q. ChIP-seq predicted estrogen receptor biding sites in human breast cancer cell line MCF7. Tumour Biol. 2014 May;35(5):4779-84. doi: 10.1007/s13277-014-1627-4. Epub 2014 Jan 28. PubMed PMID: 24470138. 44. Yang L, Yang S, Liu J, Wang X, Ji J, Cao Y, Lu K, Wang J, Gao Y. Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer. Exp Mol Pathol. 2014 Apr;96(2):235-41. doi: 10.1016/j.yexmp.2014.02.011. Epub 2014 Mar 3. PubMed PMID: 24602846. 45. Huang C, Xie D, Cui J, Li Q, Gao Y, Xie K. FOXM1c promotes pancreatic cancer epithelial-to-mesenchymal transition and metastasis via upregulation of expression of the urokinase plasminogen activator system. Clin Cancer Res. 2014 Mar 15;20(6):1477-88. doi: 10.1158/1078-0432.CCR-13-2311. Epub 2014 Jan 22. PubMed PMID: 24452790; PubMed Central PMCID: PMC3959252. 46. Luo JH, Zhou J, Gao Y. Correlation between periostin and SNCG and esophageal cancer invasion, infiltration and apoptosis. Asian Pac J Trop Med. 2013 Jul;6(7):516-9. doi: 10.1016/S1995-7645(13)60088-7. PubMed PMID: 23768821. 47. Jiang H, Lin Y, Yang CQ, Li Q, Luo J, Zhou Y, Xue J, Wei W, Gao Y. Quantitative assessment of the association between XRCC6 C1310G polymorphism and cancer risk. Tumour Biol. 2013 Apr;34(2):779-85. doi: 10.1007/s13277-012-0607-9. Epub 2012 Dec 28. PubMed PMID: 23271361. 48. Li Q, Gao Y, Xu ZG, Jiang H, Yu YY, Zhu ZG. Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer. Clin Exp Med. 2013 Feb;13(1):11-9. doi: 10.1007/s10238-011-0174-1. Epub 2012 Jan 11. PubMed PMID: 22234797. 49. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012 Sep;143(3):799-810.e2. doi: 10.1053/j.gastro.2012.05.043. Epub 2012 Jun 4. PubMed PMID: 22677193; PubMed Central PMCID: PMC3653768. 50. Jiang H, Zhang X, Luo J, Dong C, Xue J, Wei W, Chen J, Zhou J, Gao Y, Yang C. Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells. Mol Med Rep. 2012 Sep;6(3):575-80. doi: 10.3892/mmr.2012.943. Epub 2012 Jun 11. PubMed PMID: 22692246.