长期从事心血管疾病临床和基础研究工作；擅长各种心血管疾病临床诊治和微创介入诊治技术；擅长冠脉腔内影像和生理功能评估等先进诊治技术，在疑难危重冠心病方面具有丰富的诊治经验并处于国内领先水平。聚焦心血管热点问题，围绕动脉粥样硬化、冠心病和急性心肌梗死开展系列临床、基础及转化研究，在冠脉内皮功能障碍、细胞衰老、动脉粥样硬化炎症、血栓形成和血小板活性等分子机制领域取得一定研究成果；IVUS、OCT和FFR、QFR、RWS等影像、生理技术精准评估动脉粥样病变形态、稳定性和指导冠心病介入诊治在国际期刊发表系列文章；新型炎症生物标记物早期预警“易损斑块”、”斑块侵蚀“型心梗及预测临床预后等研究引领临床新视角。在美国AHA、TCT，欧洲ESC及韩国和巴西等国际著名心血管会议交流学术成果。国内和国际推广优化冠脉介入技术及精准治疗理念。在JACC Cardiovasc Interv ，JACC Cardiov Imaging, JAHA，Eurointervention等国际权威期刊以第一或通讯作者发表SCI论文等50余篇，编著专著15部；作为项目负责人主持国家自然科学基金项目3项、上海市科技创新行动计划重点项目1项、国家科技部项目1项、上海市优秀学术带头计划1项、上海市医学领军人才计划1项、上海市产学研医项目1项等；作为主要负责人承担国家863计划1项、卫生部重点学科课题2项等。作为主要完成人获上海市科学技术奖一等奖，中华医学科技奖三等奖，教育部科学技术进步奖一等奖，上海市科学技进步奖一等奖。获得上海市优秀学术带头人、上海市医学领军人才、上海市五一劳动奖章、上海市医务工匠、国之名医等荣誉。 在国内最先参与研制中国可降解涂层的药物洗脱支架，并最早发表国内研究发现，填补国内可降解药物洗脱支架领域空白。在国内率先引入“支架失败”理念和并开展系列临床技术研究，国际上首次提出“弥漫性支架扩张不良”是支架失败的重要机制，引起国际权威同行的关注，为降低PCI死亡率提供重要依据；国际上最早揭示心肌桥OCT上的特征性“FUSIFORM现象”及壁冠脉“腔小壁薄”的组织特性，为预防重大手术并发症提供临床依据。基于技术特色和优势，2013年起每年主办上海“优化PCI学术研讨会”，累计1万余人参加；举办实践培训班，吸引东南亚和全国100人次心血管医生来院进修学习，推动冠脉病变诊疗理念与技术的革新。近年来带领团队筛选和验证心梗早期预警生物标志物，完成1500余例心梗患者长期随访，同时基于QFR技术，致力探索心梗患者的个体化治疗策略。 出版专著： 《血管内超声（第二版）》              副主编       人民卫生出版社,2018 《2019现代心脏病学进展》             副主编       科学出版社,2019.5 《2018现代心脏病学进展》             副主编       科学出版社,2018.5 《血管内超声中国专家共识》          主笔编者    中华心血管病杂志,2018.5 《2017现代心脏病学进展》             副主编       科学出版社,2017.5 《OCT中国专家共识》                     编者          中华心血管病杂志,2017.1 《2016现代心脏病学进展》             副主编       科学出版社,2016.5 《OCT临床应用进展》                     副主编       科学技术出版社,2015 《冠状动脉疾病影像学》                  副主编       北京大学医学出版社,2015 《2015现代心脏病学进展》              副主编       科学出版社,2015 《2014现代心脏病学进展》              副主编       复旦大学出版社,2014 《现代心脏病学》                            主编助理    复旦大学出版社,2011 《实用内科学（第13版）》              编者           人民卫生出版社,2009 《冠状动脉慢性闭塞病变介入治疗》编者          人民卫生出版社,2009 《内科学》八年制英文教材              编者           人民卫生出版社,2007 《实用心脏病学（第4版）》            编者           上海科技出版社,2007 《Handbook of Complications duringPercutaneous Coronary Interventions》 编者       CRC Press出版社,2006 科技奖项： 2010年 上海市科学技术奖一等奖 2009年 上海市科学技术进步一等奖 2009年 教育部科学技术进步奖一等奖 2009年 中华医学科技奖三等奖 2005年 上海市科学技术进步一等奖 论文： 1.       Jiapeng Chu, Deqiang Yuan,  Yan Lai, Wen Ye, Lei Liu, Hao Lin, Fan Ping,  Guoqi Zhu, Fei Chen,  Yian Yao, Wenwen Yan, and Xuebo Liu. Prognostic Implications of Changes in Total Physiological Atherosclerotic Burden in Patients With Coronary Artery Disease—A Serial QFR Study. Angiology. 2023 Nov 23   Vol. 0(0) 1–9 2.       Hao Lin, Jiapeng Chu, DeqiangYuan, Kangwei Wang, Fei Chen, Xuebo Liu.MiR-206 may regulate mitochondrial ROS contribute to the progression of Myocardial infarction via TREM1.BMCCardiovascular Disorders.(2023) 23:470 3.       Haoran Ding, Guoqi Zhu, HaoLin, Jiapeng Chu, Deqiang Yuan, Yi’an Yao, Yanhua Gao, Fei Chen, Xuebo Liu. Screening of Potential Circulating Diagnostic Biomarkers and Molecular Mechanisms of Systemic Lupus Erythematosus-Related Myocardial Infarction by Integrative Analysis.Journal of Inflammation Research.2023;16：3119-3134 4.       Haoran Ding, Guoqi Zhu, HaoLin, Jiapeng Chu, Deqiang Yuan, Yi’an Yao, Yanhua Gao, Fei Chen, Xuebo Liu. Comprehensive Analysis of Atherosclerotic Plaques Reveals Crucial Genes and Molecular Mechanisms Associated with Plaque progression and Rupture.Front Cardiovasc Med.28March 2023;10 5.       Jian-ming Wei, Yan-li Song,Huan Zeng, Wen-wen Yan, Xue-bo Liu. Assessing causality between different riskfactors and pulmonary embolism: A Mendelian randomization study. FRONTIERS INCARDIOVASCULAR MEDICINE.FEB 23 2023；10卷 6.       Jiapeng Chu, Yan Lai, WenwenYan, Yian Yao, Hao Lin, Deqiang Yuan, Fan Ping,Guoqi Zhu, Zi Ye, Tongqing Yao,Fei Chen, Xuebo Liu. Impact of Radial Wall Strain on Serial Changes in VascularPhysiology in Patients with Intermediate Coronary Stenosis.Rev. Cardiovasc. Med.2023;24(8): 245 7.       Deqiang Yuan, Jiapeng Chu,Hao Lin, Guoqi Zhu, Jun Qian,Yunan Yu, Tongqing Yao, Fan Ping, Fei Chen, XueboLiu. Mechanism of homocysteine-mediated endothelial injury and its consequencesfor atherosclerosis.FRONTIERS IN CARDIOVASCULAR MEDICINE.JAN 16 2023； 9卷 8       Jiapeng Chu, Hao Lin, WenwenYan, Deqiang Yuan, Yan Lai, Xuebo Liu. Angiographic Quantitative Flow Ratio in Acute Coronary Syndrome: Beyond a Tool to Define Ischemia-causing Stenosis – A.Cardiovascular Diagnosis and Therapy.2022;12(6):892-907 9.       Hong-Wei Tan, Wei-Dong Gao,Xin-Hua Wang, Zhi-Song Chen,Xue-Bo Liu. A Four-Stepwise ElectrocardiographicAlgorithm for Differentiation of Ventricular Arrhythmias Originated from LeftVentricular Outflow Tract. Journal of clinical medicine.2022.10 10.      Jun Qian, Yanhua Gao, YanLai, Zi Ye, Yian Yao, Keke Ding, Jing Tong, Hao Lin ,Guoqi Zhu, Yunan Yu,Haoran Ding, Deqiang Yuan, Jiapeng Chu,Fei Chen, Xuebo Liu. Single-cell RNAsequencing of peripheral blood mononuclear cells from acute myocardialinfarction.Frontiers in Immunology-Inflammation.2022 11.     Jing Tong, Bing Ji, Yan-Hua Gao, Hao Lin, Fan Ping, Fei Chen,Xue-Bo Liu. Sirt6 regulates autophagy in AGE-treated endothelial cells via KLF4.Nutrition,metabolism and cardiovascular diseases.2022.03；32.755-764 12.     Guoqi Zhu , Yan Lai, Fei Chen, Jun Qian, Hao Lin, Deqiang Yuan,Tongqing Yao,and XueBo Liu. Exploration of the Crucial Genes and MolecularMechanisms Mediating Atherosclerosis and Abnormal Endothelial Shear Stress. DISEASEMARKERS.2022-08-12卷2022；页6306845 13.     Jiani Tang,Hanjing Hou ,JiapengChu,Fei Chen,Yian Yao,Yanhua Gao,ZiYe,Shaowei Zhuang ,Yan Lai,Xuebo Liu. Clinicalimplication of quantitativeflow ratio to predict clinical events afterdrug-coated balloon angioplasty inpatients with in-stent restenosis. ClinCardiol. 2021 Jul;44(7):978-986. 14.    Hongwei Tan,ZhisongChen,FeiChen,Wenjun Xu,Xuebo Liu. CKAP4 participates in tryptase-induced phenotypic conversion in atrial fibroblasts through PAR2/p38/JNK pathway. Am JTransl Res.2021;13(4):2270-2282. 15.    Zhi-Song Chen,Hong-WeiTan,Hao-Ming Song, Wen-Jun Xu,Xue-Bo Liu. Impact of corrected sinusnoderecovery time in predicting recurrence in patients with paroxysmalatrialfibrillation. J Int Med Res. 2021 May;49(5). 16.    Jun Qian,Jiyong Zan,LijunKuang,LinChe,Yunan Yu,Ting Shen, Jiani Tang,Fei Chen,Xuebo Liu. A predictivenomogram ofbleeding risk in patients with atrial fibrillation afterdrug-eluting stentimplantation. Ann Transl Med. 2021.02;20:3971；VOL9,NO3. 17.    Jiani Tang,Jiapeng Chu,HanjingHou,YanLai,Shengxian,Fei Chen,Yian Yao,Zi Ye1,Yanhua Gao,Yu Mao,ShaoweiZhuang,XueboLiu. Clinical implication of QFR in patients with ST-segementelevationmyocardial infarction after drug-eluting stent implantation. Int JCardiovascImaging. 2021 Mar;37(3):755-766. 18.    Jiani Tang,YanLai,ShengxianTu,Fei Chen,Yian Yao,Zi Ye,Jianyun Gu,Yanhua Gao,ChunyuGuan,Jiapeng Chu,ChengYang,Xuebo Liu. Quantitative Flow Ratio guided ResidualFunctional SYNTAX Scorefor Risk Assessment in Patients with ST-Segment Elevation Myocardial Infarction undergoing Percutaneous Coronary Intervention. Eurointervention. 2021 Jul20;17(4):e287-e293. 19.    Jun Qian,Lijun Kuang, LinChe,Fei Chen, Xuebo Liu. Maximum blood glucose levels during hospitalisation  to predict mortality in patients with acute coronary syndrome: aretrospectivecohort study. BMJ Open. 2020 Dec 12;1012(12). 20.    Jiapeng Chu,Jiani Tang,YanLai,Yanhua Gao, Zi Ye, Chunyu Guan, Keke Ding, Yian Yao, Fei Chen,Xuebo Liu.Associationof Stress Hyperglycemia Ratio with Intracoronary Thrombus Burden inDiabeticPatients with ST-segment Elevation Myocardial Infarction. Journal ofThoracicDisease. 2020 Nov;1211(11);6598-6608. 21.    Yun Kai Wang,Jia Ni Tang,LuHan,XianDong Liu,Yun Li Shen,Chun Yu Zhang, Xue Bo Liu. Elevated FURIN levelsinpredicting mortality and cardiovascular events in patients withacutemyocardial infarction. Metabolism. Volume 111, October 2020, 154323. 22.    Jie Zhang,JiaqiWang,HanYu,Guanghua Wang,Junfang Zhang,Rui Zhu,Xuebo Liu,Jue Li. ComparisonBetweenAtorvastatin and Rosuvastatin on Secondary Percutaneous CoronaryInterventionRate and the Risk Factors in Patients with Coronary Heart Disease.Curr. DrugMetab. 2020;2110(10). 23.    Ye Zi,Yao Yi-An,JiBing,LaiYan,Tong Jing,Guan Chun-Yu,Ping Fan,Lin Hao,Tang Jia-Ni, HouHan-Jin,ChenFei,Liu Xue-Bo. Sirt6-induced autophagy restricted TREM-1-mediatedpyroptosisin ox-LDL-treated endothelial cells: relevance to prognostication ofpatientswith acute myocardial infarction. Cell Death Discovery. ( 2019)5 :88. 24.    Zi Ye,Yan Lai,Yian Yao,GaryS.Mintz,Xuebo Liu .Optical coherence tomography and intravascularultrasoundassessment of the anatomic size and wall thickness of a muscle bridgesegment.Catheter Cardiovasc Interv. 2019.2.21;1-7. 25.    Yun Kai Wang,Jia Ni Tang,JunBoGe,Xue Bo Liu,et al. Prognostic Utility of sTREM-1 in Predicting MortalityandCardiovascular Events in Patients with Acute Myocardial Infarction. J AMHeartAssoc. 2018.6.19;7(12):e008985. 26.    Jing Tong,YanLai,FeiChen,Xue-Bo Liu,et al. Qiliqiangxin rescues mouse cardiac functionbyregulating AGTR1/TRPV1-mediated autophagy in STZ-induced diabetesmellitus.Cellular physiology and biochemistry. 2018;47（4）:1365-1376. 27.    Yu Luo, Jiani Tang, andXueboLiu etc. Coronary artery aneurysm differs from coronary arteryectasia:angiographic characteristics and cardiovascular risk factors analysisinpatients referred for coronary angiography. ANGIOLOGY. 28.    Xiaodong Wang,YanLai,YuLuo,Xumin Zhang,Hua Zhou,Zi Ye, Jiani Tang,Xuebo Liu. Relationshipbetweenclopidogrel‑related polymorphisms and variableplatelet reactivity at 1year: A cohort study from Han Chinese. J Res Med Sci.2016; 21: 111. 29.    Yu Luo,Jimin Li,XuLiu,JianfengXu,Zi Ye,Yian Yao,Xuebo Liu,Yan Lai. Combination of P2Y12 reactionunit andpercentage of platelet inhibition assessed by VerifyNow P2Y12 assay isa usefulpredictor of long-term clinical outcomes in patients with acutecoronarysyndrome undergoing percutaneous coronary intervention. Thromb. Res.2016Mar;139：114-120. 30.    XUMINZHANG,XIAODONGWANG,XIAOHUI ZHOU,XIAOYE MA,YIAN YAO and XUEBO LIU. Phenotypictransformationof smooth muscle cells from porcine coronary arteries isassociated withconnexin 43. MOLECULAR MEDICINE REPORTS. 2016 Jul;14（1）：41-48. 31.    Peizhao Du,Xuebo Liu,etal.Role of miR-199b-5p in regulating angiogenesis in mousemyocardialmicrovascular endothelial cells through HSF1/VEGF pathway.EnvironmentalToxicology and Pharmacology. 2016 Oct;47：142-148. 32.    Zi Ye, Yan Lai, Xuebo Liuetal. The Unique Fusiform Appearance of Myocardial Bridging Detected byOpticalCoherence Tomography:A Combined Angiographic, Intravascular Ultrasound,andOptical Coherence Tomography Study. JACC: CardiovascularImaging.2015(10):12-13. 33.    Yunli Shen,XueboLiu,ZheyongHuang,Ning Pei,Jianfeng Xu,Zheng Li,Yunkai Wang,Juying Qian,andJunbo Ge.Comparison of Magnetic Intensities for Mesenchymal Stem Cell TargetingTherapyon Ischemic Myocardial Repair: High Magnetic Intensity Improves CellRetentionbut Has no Additional Functional Benefit. CellTransplantion.2015;24(10):1981-1997. 34.    Li Lin, Xuebo Liu, JianfengXu,Yunzeng Zou. High-density lipoprotein inhibits mechanicalstress-inducedcardiomyocyte autophagy and cardiac hypertrophy throughangiotensin II type 1receptor-mediated PI3K/Akt pathway. J. Cell. Mol. Med.2015;19:1929-1938. 35.    Ying Li, Jiming Li, XueboLiu.Inhibitory effect of atorvastatin on AGE-induced HCAEC apoptosisbyupregulating HSF1 protein. international journal ofbiologicalmacromolecules.(2013). 36.    Jiming Li, Xuebo Liu. Etal.Mechanical stretch changes coronary artery fibroblasts function byupregulatingHSF1 protein expression I.nt J Biol Macromol.2013;59:105-10. 37.    Xuebo Liu, Kenichi Tsujita,etal. Intravascular ultrasound assessment of the incidence and predictors ofedgedissections after drug-eluting stent implantation. J Am Coll CardiolIntv.2009;2; 997-1004. 38.    Xuebo Liu, Hiroshi Doi, etal.A Volumetric Intravascular Ultrasound Comparison of Early Drug-elutingStentsThrombosis vs. Drug-eluting Stent Restenosis. J Am Coll Cardiol Intv2009.5：325-329. 39.    冠状动脉介入策略中何时选择何种腔内影像学技术. 中华心血管病杂志. 2024年2月第52卷第2期. 40.    刘学波 钱菊英 葛均波.左主干冠状动脉病变的血管内超声研究. 中华心血管病杂志. 2008年11月第36卷第11期:975-979. 41.    刘学波 钱菊英 葛均波.血管内超声评价雷帕霉素洗脱支架再狭窄及早期血栓形成. 中华心血管病杂志. 2009年11月第37卷第5期:975-979. 42.    刘学波 葛均波 等. 载Rapamycin新型可降解涂层支架在猪冠状动脉模型预防再狭窄的实验研究。中华心血管病杂志. 2002年5月第30卷第5期：290-293. 43.    刘学波 刘媛 葛均波.冠状动脉血流分数储备在临界病变中应用研究。中国介入心脏病学杂志.2010年10月第11卷第5期：231-233. 44.    刘学波 葛均波 钱菊英 等.雷帕霉素支架对小型猪冠状动脉P27kip表达及内膜增殖的影响。中国介入心脏病学杂志.2003年10月第11卷第5期：230-233.