上海市医学会血管外科专科分会

郭大乔 主任医师
学会任职: 候任主任委员
所属分会: 血管外科专科分会
工作单位: 中山医院
出诊信息: 点击查看
专业: 外科学
亚专业: 血管外科
专业主攻方向: 血管外科临床与基础研究
主要学术成就、科技奖项、发明创造、著作、重要论文等

目前担任:复旦大学附属中山医院血管外科副主任、主任医师、教授、博士生导师,复旦大学血管外科研究所常务副所长 学术奖励:        1. 华夏医学科技奖一等奖(2013.12,排名第3) 2. 上海市医学科技进步奖一等奖(2013.12,排名第2) 3. 教育部科学技术进步奖二等奖(2009.01,排名第3) 4. 中华医学科技奖二等奖(2014.12,排名第3) 5. 教育部科学技术进步奖二等奖(2015.02,排名第3) 6. 上海市科技进步二等奖(2014.11,排名第3) 7. 中国医院协会医院科技创新奖三等奖(2019.07,排名第3) 8. 上海市医务职工科技创新“星光计划”三等奖(2020.12,排名第1) 9. 上海市科学技术成果推广奖三等奖(2021.11,排名第3) 近五年主持或参与科研项目 1. 2023年国家自然科学基金面上项目:SREBF1通过FAO/DNL通路介导脂代谢重编程调控斑块稳定性的机制研究(项目编号:82270517,2023.01-2026.12,主持,经费52万元) 2. 2020年国家自然科学基金面上项目:β-arrestin2介导内皮间质转化调控颈动脉斑块稳定性的研究(项目编号:81970408,2020.01-2023.12,主持,经费55万元,已结题) 3. 2019年上海市科委项目:基于多模态磁共振成像的颈动脉高危斑块筛选模型的建立及其对CAS术后微栓塞事件的预测价值(项目编号:19411966900,2019.04-2022.03,主持,经费20万元,已结题) 4. 2016年国家自然科学基金面上项目:生物钟基因Bmal1调控颈动脉斑块形成及其稳定性转变的机制研究(项目编号:81570433,2016.01-2019.12,主持,经费57万元,已结题) 5. 2014年上海市科委项目:多学科协作筛选高危颈动脉狭窄及手术方案优化的前瞻性研究(项目编号:14411962300,2014.04-2017.03,主持,经费30万元,已结题) 近五年期刊论文 1. Han T; Tang H; Lin C; Yan D; Zhou Z; Yang Y; Cai L; Zhu J; Gao B; Si Y; Fu W; Tai Z; Tang X; Guo D. “Costunolide mitigates inflammation and promotes extracellular matrix integrity of thoracic aortic dissection by inhibiting NF-κB signaling.” Int Immunopharmacol, 2024 Apr 20; 131:111784. doi: 10.1016/j.intimp.2024.111784. Epub 2024 Mar 16. PMID: 38493694. (通讯作者) 2. Han T; Tang H; Lin C; Zhu J; Shen Y; Yan D; Zhao Z; Lin J; Gao B; Si Y; Wei X; Tang X; Guo D; Fu W. “One month follow-up of carotid endarterectomy with in-hospital preoperative aspirin monotherapy and postoperative dual antiplatelet therapy in asymptomatic and symptomatic patients: A multi-center study.” Heliyon, 2024 Jan 23; 10(3):e24755. doi: 10.1016/j.heliyon.2024.e24755. PMID: 38322935; PMCID: PMC10844113. (通讯作者) 3. Han T; Pu J; Tang H; Yang S; Dong D; Lu M; Wei X; Yang G; Zhao B; Guo D; Tang X; Zhao Z. “Retrospective, multicenter study of surgical treatment for carotid body tumors with or without preoperative embolization.” Front Oncol, 2023 Mar 2; 13:1123430. doi: 10.3389/fonc.2023.1123430. PMID: 36937387; PMCID: PMC10018181. (通讯作者) 4. Han T; Tang H; Lin C; Shen Y; Yan D; Tang X; Guo D. “Extracellular traps and the role in thrombosis.” Front Cardiovasc Med, 2022 Aug 25; 9:951670. doi: 10.3389/fcvm.2022.951670. PMID: 36093130; PMCID: PMC9452724. (通讯作者) 5. Lin C; Xu L; Tang X; Li X; Lu C; Cheng Qi; Jiang J; Shen Y; Yan D; Qian R; Fu W; Guo D. “Clock Gene Bmal1 Disruption in Vascular Smooth Muscle Cells Worsens Carotid Atherosclerotic Lesions.” Arteriosclerosis, Thrombosis, and Vascular Biology, 2022, 42(5): 565-579. doi: 10.1161/ATVBAHA.121.316480. Epub 2022 Mar 3. PMID: 35236106. (通讯作者) 6. Shen Y; Xu L; Yan D; Zhou M; Han T; Lu C; Tang X; Lin C; Qian R; Guo D. “BMAL1 modulates smooth muscle cells phenotypic switch towards fibroblast-like cells and stabilizes atherosclerotic plaques by upregulating YAP1.” Biochimica Et Biophysica Acta: Molecular Basis Of Disease, 2022, 1868(9): 166450-166450. doi: 10.1016/j.bbadis.2022.166450. IF: 6.633 Q1. Epub 2022 May 20. PMID: 35598770. (通讯作者) 7. Xue S; Tang H; Zhao G; Fang C; Shen Y; Yan D; Yuan Y; Fu W; Shi Z; Tang X; Guo D. “C-C motif ligand 8 promotes atherosclerosis via NADPH oxidase 2/reactive oxygen species-induced endothelial permeability increase.” Free Radical Biology and Medicine, 2021, 167: 181-192. doi: 10.1016/j.freeradbiomed.2021.02.022. IF: 8.101 Q1. Epub 2021 Mar 17. PMID: 33741452. (通讯作者) 8. Tang H; Jiang X; Xue S; Fu W; Tang X; Guo D. “Long-Term Surgical Outcomes of Carotid Body Tumors With Pathological Fibrosis: A Cohort Study.” Front Oncol, 2021 Jul 19; 11:684600. doi: 10.3389/fonc.2021.684600. PMID: 34350114; PMCID: PMC8327168. (通讯作者) 9. Xue S; Tang H; Zhao G; Shen Y; Yang EY; Fu W; Shi Z; Tang X; Guo D. “C-C Motif Chemokine 8 promotes angiogenesis in vascular endothelial cells.” Vascular, 2021 Jun; 29(3):429-441. doi: 10.1177/1708538120959972. Epub 2020 Sep 25. PMID: 32972333. (通讯作者) 10. Xu L; Liu Y; Cheng Q; Shen Y; Yuan Y; Jiang X; Li X; Guo D; Jiang J; Lin C. “Bmal1 Downregulation Worsens Critical Limb Ischemia by Promoting Inflammation and Impairing Angiogenesis.” Front Cardiovasc Med, 2021 Aug 10; 8:712903. doi: 10.3389/fcvm.2021.712903. IF: 5.846 Q2. PMID: 34447794; PMCID: PMC8384109. (通讯作者) 11. Zhao G; Tang I; Tang H; Lin J; Xue S; Guo D. “Predictors of Ipsilateral New Ischemic Lesions on Diffusion-Weighted Imaging after Carotid Artery Stenting in Asymptomatic Patients: A Retrospective Observational Study with Conventional Multi contrast MRI.” Ann Vasc Surg, 2021 Jul; 74:95-104. doi: 10.1016/j.avsg.2020.12.022. IF: 1.607 Q4. Epub 2021 Jan 26. PMID: 33508458. (通讯作者) 12. Shen Y; Xu LR; Tang X; Lin CP; Yan D; Xue S; Qian RZ; Guo DQ. “Identification of potential therapeutic targets for atherosclerosis by analysing the gene signature related to different immune cells and immune regulators in atheromatous plaques.” BMC Med Genomics, 2021 Jun 3; 14(1):145. doi: 10.1186/s12920-021-00991-2. IF: 3.622 Q2. PMID: 34082770; PMCID: PMC8176741. (通讯作者) 13. Xue S; Tang X; Zhao G; Tang H; Shen Y; Yang EY; Fu W; Shi Z; Guo D. “Contemporary Outcomes of Open and Endovascular Intervention for Extracranial Carotid Artery Aneurysms: A Single Centre Experience.” Eur J Vasc Endovasc Surg, 2020 Sep; 60(3):347-354. 14. Shen Y; Guo D. “Predict the probability of the presence of vulnerable carotid plaque.” Ann Vasc Surg, 2020 Aug 29; S0890-5096(20)30771-8. 15. Zhao G; Tang X; Tang H; Lin J; Sun W; Fan Z; Fu C; Guo D. “Recent Intraplaque Hemorrhage Is Associated with a Higher Risk of Ipsilateral Cerebral Embolism During Carotid Artery Stenting.” World Neurosurg, 2020 May; 137:e298-e307. 16. Xue S; Tang X; Zhao G; Tang H; Cai L; Fu W; Zhang W; Yang EY; Guo D. “A Systematic review and updated meta-analysis of carotid near-occlusion.” Ann Vasc Surg, 2019 Jul; 66:636-645.e3. 17. Guo B; Dong Z; Pirola S; Liu Y; Menichini C; Xu XY; Guo D; Fu W. “Dissection Level Within Aortic Wall Layers is Associated with Propagation of Type B Aortic Dissection: A Swine Model Study.” Eur J Vasc Endovasc Surg, 2019 Sep; 58(3):415-425. 18. Yan D; Tang X; Shi Z; Wang L; Lin C; Guo D; Fu W. “Perioperative and Follow-up Results of Carotid Artery Stenting and Carotid Endarterectomy in Patients with Carotid Near-Occlusion.” Ann Vasc Surg, 2019 Aug; 59:21-27. 参加教材编写 1. 高等学校“十四五”医学规划新形态教材《外科学》第二版 2. 普通高等学校“十一五”国家级规划教材《外科学》第二版 授权专利 1. 郭大乔; 唐涵斐; 唐骁; 符伟国; 董智慧; 史振宇; 陈斌; 司逸; 赵格非; 薛松; 方超; 沈洋; 朱梦娇 ; 一种预开窗颈动脉抗凝涂层覆膜支架;ZL202021688049.8;2021-08-03 (专利) 2. 方超; 郭大乔; 蒋俊豪; 唐骁; 唐涵斐; 林长泼; 原野; 符伟国 ; 一种简易型一体化血管穿刺器械, 2022-3-11, 中国, ZL 2021 2 2298820.1 (专利) 3. 郭大乔,韩同磊,符伟国,唐骁,司逸,林长泼,唐涵斐,沈洋,方超,严栋,孙秀丽,蔡亮,朱家琦;一种下肢远端血流球囊保护伞一体化保护装置;ZL202220015445.7;2022-10-11(专利) 4. 韩同磊,郭大乔,符伟国,唐骁,司逸,林长泼,唐涵斐,沈洋,方超,严栋,孙秀丽,蔡亮,朱家琦;双层套叠弯曲度可变式超选导管;ZL202220016457.1;2022-10-11(专利) 5. 韩同磊,郭大乔,符伟国,唐骁,司逸,林长泼,唐涵斐,沈洋,方超,严栋,孙秀丽,蔡亮,朱家琦;腹主动脉自膨式喇叭花保护伞装置;ZL202220015542.6;2022-11-01(专利) 6. 郭大乔,韩同磊,符伟国,唐骁,司逸,林长泼,唐涵斐,沈洋,方超,严栋,孙秀丽,蔡亮,朱家琦 ;下肢动脉逆向保护伞血流保护装置;ZL202220015543.0;2022-11-01(专利) 7. 郭大乔,周振宇,唐涵斐,唐骁,陈灿,韩同磊 ; 一种用于颈动脉支架置入术的远端保护装置;ZL 202222381203.2;2023-07-07(专利) 8. 韩同磊,郭大乔,符伟国,唐骁,司逸,高斌,林长泼,唐涵斐,沈洋,严栋,孙秀丽;用于动脉内膜碎屑清除的双头花生米状装置;ZL202220700344.3;2022-11-01(专利) 9. 韩同磊,郭大乔,符伟国,唐骁,司逸,高斌,林长泼,唐涵斐,沈洋,严栋,孙秀丽;肱动脉入路腹主动脉血流保护装置;ZL202220700345.8;2022-11-11(专利) 10. 韩同磊,郭大乔,符伟国,唐骁,司逸,高斌,林长泼,唐涵斐,沈洋,严栋,孙秀丽;自膨缩口式通用型扭控器;ZL202220720265.9;2022-12-06(专利)