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何东仪 主任医师
学会任职: 主任委员
所属分会: 风湿病专科分会
工作单位: 上海市光华中西医结合医院
出诊信息: 点击查看
专业: 中西医内科
亚专业: 风湿病
专业主攻方向: 风湿病专业:类风湿性关节炎、强直性脊柱炎、痛风、干燥综合症、银屑病关节炎、反应性关节炎、红斑狼疮、骨关节炎、幼年性类风湿关节炎,原因不明关节炎等其他风湿类疾病。
主要学术成就、科技奖项、发明创造、著作、重要论文等

1.消痹膏治疗类风湿关节炎的临床和实验研究 上海市中西医结合科学技术奖三等奖 2.中药有效成分配伍治疗类风湿关节炎的研究  河北省中医药学会科学技术奖一等奖 3.(-)-表没食子儿茶素没食子酸酯对类风湿关节炎的免疫调节机理研究 上海市中西医结合科学技术奖三等奖 4.(-)-表没食子儿茶素没食子酸酯对类风湿关节炎的免疫调节机理研究 上海市科学技术成果 5.Ergotope肽段免疫干预类风湿关节炎的研究 上海医学科技奖三等奖 6.问荆合剂治疗类风湿关节炎的临床和实验研究 上海市中西医结合科学技术奖三等奖 7.基于内毒素肠渗漏机制的健脾活血方抗酒精肝损伤机理研究 中国中西医结合学会科学技术奖二等奖  2009年 8.从肾论治在针药结合治疗类风湿关节炎的临床应用及相关机制  上海市科学技术三等奖 9. 从肾论治在针药结合治疗类风湿关节炎的临床应用及相关机制 中华中医药学会科学技术三等奖 10.尪痹片等痹症系列药治疗类风湿性关节炎的基础与临床辨证应用研究 中国中西医结合学会科学技术二等奖 11.《陈氏清肺方治疗类风湿关节炎并发兼执行肺炎(RA-ILD)的临床和实验研究》,上海市中西医结合科学技术三等奖   专利 12.强直性脊柱炎和类风湿关节炎致病机理及诊疗策略的关键技术研究 上海市科学技术一等奖 专利 一种清热消肿止痛的中药制剂及其制备方法 国家发明专利(ZL 201310360885.1)2014年 论文 1.Clin Rheumatol. Correlation of serum MMP3 and other biomarkers with clinical outcomes in patients with ankylosing spondylitis: a pilot study. Clin Rheumatol.2017 Apr 22. IF: 2.042 2.Increased DOT1L in synovial biopsies of patients with OA and RA. Clin Rheumatol. Published online:13 Dec 2017. IF:2.365 3.Association of the HLA-DRB1 with scleroderma in Chinese population. PLoS One. 2014; 9(1):e87363. Publication Impact Factor: 3.234; 4.High incidence of tuberculosis infection in rheumatic diseases and impact for chemoprophylactic prevention of tuberculosis activation during biologics therapy. Clin Vaccine Immunol. 2013; 20(6):842-7. IF:2.47 5.(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.Sci Rep. 2019 Aug 1;9(1):11155. IF:4.011 6.T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB. BioMed Research International. Volume 2018. IF: 2.476 7.Alterations and diagnosis potential of serum lipid profiles in rheumatoid arthritis patints. Int J Clin Exp Pathol, 2017,10(3):3503-3509. IF:1.581 8.Genome-wide  DNA methylation patterns in CD4+ T reveal significant contribution of DNA methylation to rheumatoid arthritis. Mod Rheumatol, 2016; Early Online: 1–7. IF:1.843; 9.Clin Rheumatol. Correlation of serum MMP3 and other biomarkers with clinical outcomes in patients with ankylosing spondylitis: a pilot study. Clin Rheumatol.2017 Apr 22. IF: 2.042 10.Increased DOT1L in synovial biopsies of patients with OA and RA. Clin Rheumatol. Published online:13 Dec 2017. IF:2.365 11.Association of the HLA-DRB1 with scleroderma in Chinese population. PLoS One. 2014; 9(1):e87363. Publication Impact Factor: 3.234; 12.High incidence of tuberculosis infection in rheumatic diseases and impact for chemoprophylactic prevention of tuberculosis activation during biologics therapy. Clin Vaccine Immunol. 2013; 20(6):842-7. IF:2.47 13.(5R)-5-Hydroxytriptolide (LLDT-8) induces substantial epigenetic mediated immune response network changes in fibroblast-like synoviocytes from rheumatoid arthritis patients.Sci Rep. 2019 Aug 1;9(1):11155. IF:4.011 14.T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-κB. BioMed Research International. Volume 2018. IF: 2.476 15.Alterations and diagnosis potential of serum lipid profiles in rheumatoid arthritis patints. Int J Clin Exp Pathol, 2017,10(3):3503-3509. IF:1.581 16.Genome-wide  DNA methylation patterns in CD4+ T reveal significant contribution of DNA methylation to rheumatoid arthritis. Mod Rheumatol, 2016; Early Online: 1–7. IF:1.843; 17. (5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway. BMC Complement Altern Med. 2015 Mar 24;15:77. IF: 2.02; Times Cited: 1 18.Chen G*. Regulatory effect of iguratimod on the balance of th subsets and inhibition of inflammatory cytokines in patients with rheumatoid arthritis. Mediators Inflamm. 2015;2015:356040. IF: 3.236; 19.Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med. 2013; 9(3):322-8. IF: 28.054; Times Cited: 158 20.Wang H, Liu W, Shi Y, Harley JB, Shen N*, Qian Y*. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med. 2012; 18(7):1077-86. IF: 22.864; Times Cited: 169 21.雷公藤—抗风湿新策略.中华风湿病学杂志.2018,22(3):1-3. 22.雷藤舒(LLDT-8)通过提高MEKK2蛋白表达调控胶原诱导性关节炎小鼠Treg/Th17平衡.现代免疫学.2018,38(3):210-216. 23.新雷公藤衍生物雷藤舒对类风湿关节炎滑膜细胞基因表达的影响.上海中医药大学学报.2017,31(6):70-75. 24.雷藤舒对TNF-α诱导的人类风湿关节炎滑膜成纤维细胞促凋亡、抗炎及对Ras-MAPKs信号通路的调节作用. 上海中医药大学学报, 2016, 30(3):82-87. 25.(LLDT-8)对成纤维样滑膜细胞分泌趋化因子的影响.现代免疫学,2016,36(6):448-454. 26.消痹膏镇痛抗炎作用的实验研究.上海中医药大学学报, 2014,28(2):56-59. 27.秦氏消痹膏外敷结合西药治疗湿热痹阻型类风湿关节炎70 例.上海中医药杂志,2014,48(4):67-70. 成果:(-)-表没食子儿茶素没食子酸酯对类风湿关节炎的免疫调节机理研究