近五年第一负责人主持国家级和省部级课题3项,含科技部国家重点研发计划1项,研究经费344万;主编或副主编出版专著5部(含人卫2部),参编3部;获上海市药学科技奖三等奖2次。近五年第一或通讯作者发表SCI论文15篇。 作为学科带头人,2010年带领学科成为首批五家国家重点临床药学专科建设单位之一。2016、2017年度中国医院最佳专科声誉排行榜前十,2018年获提名。2018年入选上海市临床重点专科建设腾飞计划。近五年科技获奖有中国医药教育协会科学技术奖科技创新奖二等奖;两次上海市药学科技奖三等奖。两项专利获得授权:基于血药浓度监测的药效优化方法及装置(ZL201811043807.8);抗凝药药效优化模型的建立方法及装置(ZL201811015577.9)。 代表性SCI论文见下。 1. Huang X, Yu Z, Bu S, Lin Z, Hao X, He W, Yu P, Wang Z, Gao F, Zhang J, Chen J. An Ensemble Model for Prediction of Vancomycin Trough Concentrations in Pediatric Patients. Drug Des Devel Ther. 2021 April 14; 15:1549-1559. 2. Huang X, Yu Z, Wei X, Shi J, Wang Y, Wang Z, Chen J, Bu S, Li L, Gao F, Zhang J, Xu A. Prediction of vancomycin dose on high-dimensional data using machine learning techniques. Expert Rev Clin Pharmacol. 2021 Apr 9:1-11. 3. Liu Y, Chen J, You Y, Xu A, Li P, Wang Y, Sun J, Yu Z, Gao F, Zhang J. An ensemble learning based framework to estimate warfarin maintenance dose with cross-over variables exploration on incomplete data set. Comput Biol Med. 2021 Feb 4;131:104242. 4. Yao H, Liu J, Jiang X, Chen F, Lu X, Zhang J. Analysis of the Clinical Effect of Combined Drug Susceptibility to Guide Medication for Carbapenem-Resistant Klebsiella pneumoniae Patients Based on the Kirby-Bauer Disk Diffusion Method. Infect Drug Resist. 2021 Jan 12;14:79-87. 5. Ma J, Jiang X, Yarui A, Danli J, Xiaodie Y, Zhang J, Xu A. Ultraviolet light activates PMK-1/p38 MAPK signaling via MOM-4 and JKK-1 in Caenorhabditis elegans. Toxicol Res (Camb). 2020 Jul 13;9(4):461-466. 6. Zhang C, Zhang X, Shen J, Lu X, Zhang J, Chen S. Changes in Peripheral Blood Neutrophils, Lymphocytes and IL-10 in Children with Kawasaki Disease from Different Age Groups Undergoing Intravenous Immunoglobulin: A Retrospective Study. Mediators Inflamm. 2020 Nov 18;2020:5213451. 7. Ma J, Wang R, Yan H, Xu R, Xu A, Zhang J. Protective Effects of Baicalin on Lipopolysaccharide-Induced Injury in Caenorhabditis elegans. Pharmacology. 2020;105(1-2):109‐117. 8. Zhang C, Yu P, Ma J, Zhu L, Xu A, Zhang J. Damage and Phenotype Change in PC12 Cells Induced by Lipopolysaccharide Can Be Inhibited by Antioxidants Through Reduced Cytoskeleton Protein Synthesis. Inflammation. 2019;42(6):2246‐2256. (IF:2.939) 9. Wang H, Yao H, Yi B, Kazama K, Liu Y, Deshpande D, Zhang J, Sun J. MicroRNA-638 inhibits human airway smooth muscle cell proliferation and migration through targeting cyclin D1 and NOR1. J Cell Physiol. 2018 Jan;234(1):369-381. (IF:4.522) 10. Xu R, Qi J, Zhan R, Zhou G, Hao B, Ma J, Wei X, Xu A, Zhang J. Comparative pharmacokinetics of four active components on normal and diabetic rats after oral administration of gandi capsules. RSC Advances, 2018;8(12):6620-6628. (IF:3.409) 11. Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y. Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology. Evid Based Complement Alternat Med. 2018 Apr 26;2018:6503126. (IF:1.984) 12. Zhang J, Liu Y, Chen T, Huang X, Zhang H, Chen X, Zhang Q, Tang Y, Chen W. Assessment of the Intestinal Permeability of Major Phytocomponents Contained in Gandi Capsules Using Ultra-High Performance Liquid Chromatography Coupled with Electrospray Ionization–Quadrupole-Time of Flight Mass Spectrometry. Chromatographia. 2018; 81:1013. (IF:1.552) 13. Xu R, Yuan Y, Qi J, Zhou J, Guo X, Zhang J, Zhan R. Elucidation of the Intestinal Absorption Mechanism of Loganin in the Human Intestinal Caco-2 Cell Model. Evid Based Complement Alternat Med. 2018 Dec 23;2018:8340563. (IF:1.984) 14. Ma J, Yan H, Wang R, Bo S, Lu X, Zhang J, Xu A. Protective effect of carnosine on white matter damage in corpus striatum induced by chronic cerebral hypoperfusion. Neurosci Lett. 2018 Sep 14;683:54-60. (IF:2.173) 15. Ma J, Bo SH, Lu XT, Xu AJ, Zhang J. Protective effects of carnosine on white matter damage induced by chronic cerebral hypoperfusion. Neural Regen Res. 2016 Sep;11(9):1438-1444. (IF:1.769)