先后主持国家自然科学基金课题2项、上海市科委课题8项等十余项研究项目。近年来累计发表中英文论著80余篇，其中SCI收录50余篇。主编专著3部，作为执笔人编写技术指南1项，参与修订2项。获得国家专利40余项。获教育部科技进步奖1项。 一、近年承担课题（第一完成人） (1) 上海市徐汇区卫健委, 一般项目, 2021013, 多模式内镜实时AI辅助诊断消化道早期肿瘤的体系建立, 2021-10 至 2023-10, 160万元, 在研, 主持 (2) 上海市科委, 一般项目, 19411951500, 消化道黏膜下肿瘤影像人工智能标准化检测体系(多中心研 究，牵头单位), 2019-07 至 2022-06, 200万元, 结题, 主持 (3) 国家重点研发计划项目（子课题）：超声内镜/共聚焦内镜复合应用的产品评价，150w (4) 国家自然科学基金面上项目， 绞股蓝皂苷A通过抑制脱硫弧菌产生硫化氢下调FXR-SHP轴预防胆囊结石的作用及其机制研究，82374215，2024.01 - 2027.12，49万元，在研，主持人：宛新建 二、近年发表的科研论文（部分） 1. Zhang W, Kanwal F, Batool AI, Mustaqeem M, Rehman MFU, Wan X. Studying in vivo and in vitro effects of a novel polyvinyl benzyl chloride-D-glucaro-1, 4-lactonate polymer-coated bile duct stent for anti-biliary mud deposition. J Appl Biomater Funct Mater 2022, 20: 22808000221134988. 2. Ye X, Huang D, Dong Z, Wang X, Ning M, Xia J, et al. FXR Signaling-Mediated Bile Acid Metabolism Is Critical for Alleviation of Cholesterol Gallstones by Lactobacillus Strains. Microbiol Spectr 2022, 10(5): e0051822. 3. Wang J, Xia M, Jin Y, Zheng H, Shen Z, Dai W, et al. More Endoscopy-Based Brushing Passes Improve the Detection of Malignant Biliary Strictures: A Multicenter Randomized Controlled Trial. The American journal of gastroenterology 2022, 117(5): 733-739. 4. Ni J, Peng K, Yu L, Xie H, Luo S, Xu K, et al. Transpapillary Stenting Improves Treatment Outcomes in Patients Undergoing Endoscopic Transmural Drainage of Ductal Disruption-Associated Pancreatic Fluid Collections. The American journal of gastroenterology 2022. 5. Guo L, Yu L, Zhao Q, Gong X, Xie H, Yuan G, et al. Biodegradable JDBM coating stent has potential to be used in the treatment of benign biliary strictures. Biomedical materials (Bristol, England) 2021, 16(2): 025010. 6. Zheng H, Zhuang Q, Wan X. A Rare Case of Cholangiocarcinosarcoma Masquerading as a Cholangiolithiasis Observed by ERCP. Dig Dis Sci 2023. 7. Dong Z, Xia J, Wan X. A rare helicobacter pylori infection-negative early gastric cancer in a young man with primary hypertrophic osteoarthropathy. Endoscopy 2022, 54(11): E612-e614. 8. Zheng H, Zhu M, Li W, Zhou Z, Wan X. m5 C and m6 A modification of long noncoding NKILA accelerates cholangiocarcinoma progression via the miR-582-3p-YAP1 axis. Liver international : official journal of the International Association for the Study of the Liver 2022, 42(5): 1144-1157. 9. Zhuang Q, Cheng J, Xia J, Ning M, Wu S, Shen S, et al. Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids. Frontiers in medicine 2022, 9: 818144. 10. Zhuang Q, Ye X, Shen S, Cheng J, Shi Y, Wu S, et al. Astragalus Polysaccharides Ameliorate Diet-Induced Gallstone Formation by Modulating Synthesis of Bile Acids and the Gut Microbiota. Frontiers in pharmacology 2021, 12: 701003. 三、主编（译）专著 1. 项平, 宛新建. 大肠肿瘤基础及临床进展，上海科技出版社, 413千字，2007 2. 李兆申, 宛新建, 刘枫. 消化内镜的质量控制，上海科技出版社, 268千字，2009[3] 3. 宛新建, 胡冰, 刘枫. 高级消化内镜:ERCP(译)，上海科技出版社, 411千字，2009