1. 主要学术成就     作为第一负责人承担3项国家自然基金面上项目，上海市科委、上海市卫计委等各级课题30余项；以第一作者或通讯作者在国内外期刊发表论文150余篇，其中SCI收录60余篇，总影响因子305.959；参编专著6部；授权专利2项。 2. 科技奖项     以第一完成人获2017年度上海药学科技三等奖、第十七届上海中西医结合科学技术奖二等奖、2024年度中国中西医结合学会科学技术奖三等奖。 3. 发明创造     近五年申请国家发明专利8项，其中2项已授权： [1] 原永芳, 宫春爱, 韩璐, 俞晓艳, 王彧杰，王蓉, 一种靶向整合素αvβ3的外泌体载体及其制备方法和应用, 2019-4-23, 中国, 201811600908.0（已授权） [2] 原永芳, 陈继源, 韩璐, 王蓉, 宫春爱, 一种仿生磁靶向阳离子脂质体及其制备方法和应用, 2021-9 -18,中国, 202111098725.5（已授权） [3] 原永芳, 王蓉, 陈盼盼, 顾妍秋, 陈继源, 李胜男, 一种具有保肝作用的中药活性单体及其用途, 2022-10-26, 中国, 202211328489.6 [4] 原永芳, 郝军, 吴飞华, 韩璐, 王蓉, 陈敏燕, 陈继源, 陈晓文, 杨盟, 一种祛腐生肌软膏及其制备方法和应用, 2021-12-10, 中国, 202111503280.4 [5] 原永芳, 宫春爱, 韩璐, 俞晓燕, 王彧杰, 王蓉, 一种多重靶向的融合细胞膜修饰的仿生纳米递送系 统及其制备方法与应用, 2020-6-8, 中国, 202010510913.3 [6] 原永芳, 郝军, 吴飞华, 韩璐, 王蓉, 陈敏燕, 陈晓文, 杨盟, 一种创面修复软膏及其制备方法和应用, 2020-6-8, 中国, 202010510918.6 [7] 陈啸飞, 原永芳, 顾妍秋, 陈盼盼, 王蓉, 柴逸峰, 一种膜蛋白原位合成亲和生物色谱柱及其制备方法和应用, 2022-10-26, 中国, 202211316472.9 [8] 原永芳, 王蓉, 李胜男, 陈盼盼, 陈继源, 顾妍秋, 柳方彬，戈米辛N及其衍生物在肝损伤相关疾病治疗中的用途, 2023-05-25,中国, 202310598136.6 4. 重要论文     在国内外期刊发表论文150余篇，其中SCI收录60余篇，总影响因子305.959。其中近三年以通讯作者发表SCI论文26篇，影响因子大于5分的SCI论文如下： [1] Chengliang Wang, Yanqiu Gu, Chun Chen, Yanting Li, Ling Li, Yifeng Chai, Zhengjin Jiang,*Xiaofei Chen,*, Yongfang Yuan*. One-Step Synthesis and Oriented Immobilization of Strep-Tag II Fused PDGFRβ for Screening Intracellular Domain-Targeted Ligands. Analytical Chemistry. 2024, 96(28):11479-11487. [2] Yanqiu Gu#, Rong Wang#, Panpan Chen#, Shengnan Li, Xinyi Chai, Chun Chen, Yue Liu, Yan Cao, Diya Lv, Zhanying Hong, Zhenyu Zhu, Yifeng Chai*, Yongfang Yuan*, Xiaofei Chen*. In situ synthesis and unidirectional insertion of membrane proteins in liposome-immobilized silica stationary phase for rapid preparation of microaffinity chromatography. Acta Pharmaceutica Sinica B. 2022, 12(9): 3682-3693. [3] Yanqiu Gu#, Xiao Chen#, Yao Wang#, Yue Liu, Leyi Zheng, Xiaoqun Li, Rong Wang, Shaozhan Wang, Shengnan Li, Yifeng Chai, Jiacan Su*, Yongfang Yuan*, Xiaofei Chen*. Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix. Acta Pharmaceutica Sinica B. 2020, 10(10): 1856-1865. [4] Panpan Chen#, Rong Wang#, Fangbin Liu#, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan*. Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways. Frontiers Pharmacology. 2023, 14:1092151. [5] Fangbin Liu#, Shengnan Li#, Panpan Chen#, Yanqiu Gu, Shaozhan Wang, Lei Wang, Chun Chen, Rong Wang*，Yongfang Yuan*. Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ. International Immunopharmacology. 2023, 122: 110550. [6] Rong Wang#, Fangbin Liu#, Panpan Chen#, Shengnan Li, Yanqiu Gu, Lei Wang, Chun Chen, Yongfang Yuan*. Gomisin D alleviates liver fibrosis through targeting PDGFRβ in hepatic stellate cells. International Journal of Biological Macromolecules. 2023, 235:123639. [7] Yueyue Li#, Jingjie Li#, Yuhuan Shi, Xuhui Zhou, Wanqing Feng, Lu Han, Daqing Ma, Hong Jiang*, Yongfang Yuan*. Urinary Aromatic Amino Acid Metabolites Associated With Postoperative Emergence Agitation in Paediatric Patients After General Anaesthesia: Urine Metabolomics Study. Frontiers in Pharmacology. 2022, 13: 932776. [8] Rong Wang#, Shengnan Li#, Panpan Chen#, Xin Yue, Shaozhan Wang, Yanqiu Gu, Yongfang Yuan*. Salvianolic acid B suppresses hepatic stellate cell activation and liver fibrosis by inhibiting the NF-κB signaling pathway via miR-6499-3p/ LncRNA-ROR. Phytomedicine, 2022, 107, 154435. [9] Jiyuan Chen#, Yujie Wang#, Lu Han#, Rong Wang, Chunai Gong, Gang Yang, Zhe Li, Shen Gao, Yongfang Yuan*. A ferroptosis-inducing biomimetic nanocomposite for the treatment of drug-resistant prostate cancer. Materials Today Bio. 2022, 17:100484. [10] Zhe Li#, Gang Yang#, Rong Wang, Yuanyuan Wang, Jing Wang, Meng Yang, Chunai Gong, Yongfang Yuan*.γ-Cyclodextrin metal-organic framework as a carrier to deliver triptolide for the treatment of hepatocellular carcinoma. Drug delivery and translational research. 2022, 12(5): 1096-1104. [11] Chunai Gong#, Xiaoyan Yu#, Wei Zhang#, Lu Han, Rong Wang, Yujie Wang, Shen Gao*, Yongfang Yuan*. Regulating the immunosuppressive tumor microenvironment to enhance breast cancer immunotherapy using pH‑responsive hybrid membrane‑coated nanoparticles. Journal of Nanobiotechnology. 2021, 19(1): 58. [12] Zhe Li#, Gang Yang#, Lu Han#, Rong Wang, Chunai Gong, Yongfang Yuan*. Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camoufaged liquid crystalline lipid nanoparticles for the treatment of hepatocellular. Journal of Nanobiotechnology. 2021, 19(1): 360. [13] Yueyue Li#, Diya Lv#, Rong Liu, Yuhuan Shi, Rong Wang, Zhenyu Zhu, Yongfang Yuan*. Non-target metabolomic analysis reveals the therapeutic effect of Saposhnikovia divaricata decoction on collagen-induced arthritis rats. Journal of Ethnopharmacology. 2021, 271: 113837.